Summary of GRB14
The Function of GRB14
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Protein names
Recommended name:
Growth factor receptor-bound protein 14Alternative name(s):
GRB14 adapter protein- RS11891401 (GRB14) ??
- RS13002573 (GRB14) ??
- RS1446468 (GRB14) ??
- RS16849225 (GRB14) ??
- RS3923113 (GRB14) ??
- RS4423615 (GRB14) ??
- RS4487103 (GRB14) ??
- RS7576072 (GRB14) ??
- RS76833157 (GRB14) ??
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Top Gene-Substance Interactions
GRB14 Interacts with These Diseases
| Disease | Score |
Substances That Increase GRB14
| Substances | Interaction | Organism | Category |
Substances That Decrease GRB14
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.