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  3. GRB14

GRB14 (Growth factor receptor bound protein 14)

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Summary of GRB14

This gene encodes a protein that binds with growth factor receptors. It interacts with insulin receptors and insulin-like growth-factor receptor and may play a role in signaling pathways that regulate growth and metabolism (R).

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The Function of GRB14

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Protein names

Recommended name:

Growth factor receptor-bound protein 14

Alternative name(s):

GRB14 adapter protein

GRB14 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11891401 (GRB14) ??
  2. RS13002573 (GRB14) ??
  3. RS1446468 (GRB14) ??
  4. RS16849225 (GRB14) ??
  5. RS3923113 (GRB14) ??
  6. RS4423615 (GRB14) ??
  7. RS4487103 (GRB14) ??
  8. RS7576072 (GRB14) ??
  9. RS76833157 (GRB14) ??

Top Gene-Substance Interactions

GRB14 Interacts with These Diseases

Disease Score

Substances That Increase GRB14

Substances Interaction Organism Category

Substances That Decrease GRB14

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Nkx2-2
  • Sox5

Tissue specificity:

Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.

Gene Pathways:

  • Hemostasis

Molecular Function:

  • Sh3/Sh2 Adaptor Activity

Biological Processes:

  • Leukocyte Migration
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_07511| AS27_06678| CB1_000616004| D623_10035585| EH28_22239| GRB14 adapter protein| growth factor receptor-bound protein 14| Growth factor receptor-bound protein 14 isoform 4-like protein| growth factor receptor-bound protein 14-like protein| H920_16145| I79_013790| M91_20325| M959_07138| N300_10106| N301_03123| N302_06807| N303_07178| N305_06574| N306_04100| N307_06993| N308_12680| N309_04756| N310_08247| N311_03912| N312_01775| N320_09213| N321_02263| N322_08921| N324_12522| N325_02537| N326_12124| N327_00888| N328_06849| N329_05821| N330_03495| N331_02168| N332_04876| N333_00764| N334_05080| N335_09223| N339_03799| N340_14665| N341_09297| TREES_T100019818| UY3_04036| Y1Q_031816| Y956_02218| Z169_02806| grb14

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