Summary of GPX3
This gene encodes a protein that functions in the detoxification of hydrogen peroxide (R).
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The Function of GPX3
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Protein names
Recommended name:
Glutathione peroxidase 3Alternative name(s):
GPx-3GSHPx-3
Extracellular glutathione peroxidase
Plasma glutathione peroxidase
GPx-P
GSHPx-P
- RS2070593 (GPX3) ??
- RS3805435 (GPX3) ??
- RS3828599 (GPX3) ??
- RS8177412 (GPX3) ??
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Top Gene-Substance Interactions
GPX3 Interacts with These Diseases
| Disease | Score |
Substances That Increase GPX3
| Substances | Interaction | Organism | Category |
Substances That Decrease GPX3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Secreted in plasma.
Molecular Function:
Biological Processes:
- Hydrogen Peroxide Catabolic Process
- Protein Homotetramerization
- Response To Lipid Hydroperoxide
- Response To Reactive Oxygen Species