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  3. GPX3

GPX3 (Glutathione peroxidase 3)

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Summary of GPX3

This gene encodes a protein that functions in the detoxification of hydrogen peroxide (R). 

0 users want this gene increased, 0 users want it decreased

The Function of GPX3

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

Protein names

Recommended name:

Glutathione peroxidase 3

Alternative name(s):

GPx-3
GSHPx-3
Extracellular glutathione peroxidase
Plasma glutathione peroxidase
GPx-P
GSHPx-P

GPX3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2070593 (GPX3) ??
  2. RS3805435 (GPX3) ??
  3. RS3828599 (GPX3) ??
  4. RS8177412 (GPX3) ??

Top Gene-Substance Interactions

GPX3 Interacts with These Diseases

Disease Score

Substances That Increase GPX3

Substances Interaction Organism Category

Substances That Decrease GPX3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • Sp1

Tissue specificity:

Secreted in plasma.

Gene Pathways:

  • Glutathione metabolism
  • Cellular responses to stress
  • Arachidonic acid metabolism

Molecular Function:

  • Glutathione Peroxidase Activity
  • Selenium Binding
  • Transcription Factor Binding

Biological Processes:

  • Hydrogen Peroxide Catabolic Process
  • Protein Homotetramerization
  • Response To Lipid Hydroperoxide
  • Response To Reactive Oxygen Species

Drug Bank:

  • Glutathione
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_14523| AS27_12001| CB1_000163015| D623_10034765| EGPx| extracellular glutathione peroxidase| extracellular GPx| glutathione peroxidase 3 (plasma)| GPx| GPx-3| gpx3-a| gpx3-b| gpx-p| Gpxp| GSHPx-3| gshpx-p| H920_12023| I79_005447| M91_14332| M959_08417| MDA_GLEAN10025684| N300_10577| N301_12191| N302_05254| N303_03226| N305_02857| N306_11974| N307_10138| N308_09114| N309_09677| N310_07619| N320_05635| N325_06966| N331_06875| N332_08387| N333_04335| N335_09384| N340_07199| PAL_GLEAN10018768| plasma glutathione peroxidase| Plasma glutathione peroxidase precursor isoform 1-like protein| Plasma glutathione peroxidase precursor-like protein| plasma GPx| UY3_18250| Y1Q_015502| Y956_02356| Z169_06171| gpx3

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