Summary of GPX1
GPX1 encodes a member of the glutathione peroxidase family, which contains important antioxidant enzymes and helps detoxify hydrogen peroxide with glutathione, and thereby protect cells against oxidative damage (R). It protects the hemoglobin in red blood cells from oxidative breakdown.
H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of antioxidant balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes.
It is also a selenoprotein, requiring selenium to function.
Associated with risk for breast cancer (R).
Protein names
Recommended name:
Glutathione peroxidase 1Alternative name(s):
GPx-1GSHPx-1
Cellular glutathione peroxidase
- RS1050450 (GPX1) ??
- RS1800668 (GPX1) ??
- RS3448 (GPX1) ??
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Top Gene-Substance Interactions
GPX1 Interacts with These Diseases
| Disease | Score |
Fixes
Methods to Increase GPX1 levels:
- Increased intake of Selenium [R].
- Increaased intake of Glutathione.
- Increased intake of NAC.
- Increased intake of Alpha-Lipoic Acid.
Substances That Increase GPX1
| Substances | Interaction | Organism | Category |
Substances That Decrease GPX1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Response To Reactive Oxygen Species
- Temperature Homeostasis
- Endothelial Cell Development
- Negative Regulation Of Inflammatory Response To Antigenic Stimulus
- Purine Nucleotide Catabolic Process
- Triglyceride Metabolic Process
- Glutathione Metabolic Process
- Response To Oxidative Stress
- Sensory Perception Of Sound
- Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
- Response To Xenobiotic Stimulus
- Response To Symbiotic Bacterium
- Uv Protection
- Response To Selenium Ion
- Response To Gamma Radiation
- Protein Oxidation
- Lipoxygenase Pathway
- Response To Hydroperoxide
- Regulation Of Mammary Gland Epithelial Cell Proliferation
- Cellular Response To Oxidative Stress
- Regulation Of Gene Expression, Epigenetic
- Vasodilation
- Response To Hydrogen Peroxide
- Hydrogen Peroxide Catabolic Process
- Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Skeletal Muscle Tissue Regeneration
- Regulation Of Neuron Apoptotic Process
- Blood Vessel Endothelial Cell Migration
- Fat Cell Differentiation
- Cell Redox Homeostasis
- Skeletal Muscle Fiber Development
- Myoblast Proliferation
- Interaction With Symbiont
- Positive Regulation Of Protein Kinase B Signaling
- Heart Contraction
- Angiogenesis Involved In Wound Healing
- Regulation Of Proteasomal Protein Catabolic Process
- Negative Regulation Of Release Of Cytochrome C From Mitochondria
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Negative Regulation Of Oxidative Stress-Induced Intrinsic Apoptotic Signaling Pathway
- Positive Regulation Of Supramolecular Fiber Organization