Summary of GPX1
GPX1 encodes a member of the glutathione peroxidase family, which contains important antioxidant enzymes and helps detoxify hydrogen peroxide with glutathione, and thereby protect cells against oxidative damage (R). It protects the hemoglobin in red blood cells from oxidative breakdown.
H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of antioxidant balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes.
It is also a selenoprotein, requiring selenium to function.
Associated with risk for breast cancer (R).
Protein names
Recommended name:
Glutathione peroxidase 1Alternative name(s):
GPx-1GSHPx-1
Cellular glutathione peroxidase
- RS1050450 (GPX1) ??
- RS1800668 (GPX1) ??
- RS3448 (GPX1) ??
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Top Gene-Substance Interactions
GPX1 Interacts with These Diseases
| Disease | Score |
Fixes
Methods to Increase GPX1 levels:
- Increased intake of Selenium [R].
- Increaased intake of Glutathione.
- Increased intake of NAC.
- Increased intake of Alpha-Lipoic Acid.
Substances That Increase GPX1
| Substances | Interaction | Organism | Category |
Substances That Decrease GPX1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Angiogenesis Involved In Wound Healing
- Blood Vessel Endothelial Cell Migration
- Cell Redox Homeostasis
- Cellular Response To Oxidative Stress
- Endothelial Cell Development
- Fat Cell Differentiation
- Glutathione Metabolic Process
- Heart Contraction
- Hydrogen Peroxide Catabolic Process
- Interaction With Symbiont
- Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
- Lipoxygenase Pathway
- Myoblast Proliferation
- Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Negative Regulation Of Inflammatory Response To Antigenic Stimulus
- Negative Regulation Of Oxidative Stress-Induced Intrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Release Of Cytochrome C From Mitochondria
- Positive Regulation Of Supramolecular Fiber Organization
- Positive Regulation Of Protein Kinase B Signaling
- Protein Oxidation
- Purine Nucleotide Catabolic Process
- Regulation Of Gene Expression, Epigenetic
- Regulation Of Mammary Gland Epithelial Cell Proliferation
- Regulation Of Neuron Apoptotic Process
- Regulation Of Proteasomal Protein Catabolic Process
- Response To Gamma Radiation
- Response To Hydrogen Peroxide
- Response To Hydroperoxide
- Response To Reactive Oxygen Species
- Response To Selenium Ion
- Response To Symbiotic Bacterium
- Response To Xenobiotic Stimulus
- Sensory Perception Of Sound
- Skeletal Muscle Fiber Development
- Skeletal Muscle Tissue Regeneration
- Temperature Homeostasis
- Triglyceride Metabolic Process
- Uv Protection
- Vasodilation
- Response To Oxidative Stress