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  3. GPT

GPT (Glutamic--pyruvic transaminase)

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Summary of GPT

Also known as DPAGT1, it encodes an enzyme that catalyzes the first step in glycoprotein biosynthesis. Mutations can cause muscle weakness and developmental disorders (R).

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The Function of GPT

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles.

Protein names

Recommended name:

Alanine aminotransferase 1

Short name:

ALT1

Alternative name(s):

Glutamate pyruvate transaminase 1
GPT 1
Glutamic--alanine transaminase 1
Glutamic--pyruvic transaminase 1

GPT SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1063739 (GPT) ??

Top Gene-Substance Interactions

GPT Interacts with These Diseases

Disease Score

Substances That Increase GPT

Substances Interaction Organism Category

Substances That Decrease GPT

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • p53

Tissue specificity:

Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Alanine, aspartate and glutamate metabolism

Induction:

By glucocorticoids.

Molecular Function:

  • L-Alanine:2-Oxoglutarate Aminotransferase Activity
  • Pyridoxal Phosphate Binding

Biological Processes:

  • Cellular Amino Acid Biosynthetic Process
  • L-Alanine Catabolic Process

Drug Bank:

  • L-Alanine
  • Phenelzine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_15574| AAT1| AlaAT| alanine aminotransferase| alanine aminotransferase 1| alanine aminotransferase 1-like protein| alanine aminotransferase 2| ALAT| ALT| ALT1| CB1_000867004| Glutamate pyruvate transaminase| glutamate pyruvate transaminase 1| glutamic--alanine transaminase 1| glutamic-alanine transaminase 1| glutamic pyruvate transaminase| glutamic-pyruvate transaminase (alanine aminotransferase)| glutamic--pyruvic transaminase 1| glutamic pyruvic transaminase 1, soluble| glutamic pyruvic transaminase (alanine aminotrasferase)| glutamic pyruvic transaminase, soluble| Gpt-1| GPT1| GPT 1| GW7_19226| H920_07995| I79_015340| N302_10724| N307_00243| PAL_GLEAN10010507| PANDA_011062| PPP1R16A| protein phosphatase 1, regulatory subunit 16A| TREES_T100008009| gpt

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