Summary of GPT
Also known as DPAGT1, it encodes an enzyme that catalyzes the first step in glycoprotein biosynthesis. Mutations can cause muscle weakness and developmental disorders (R).
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The Function of GPT
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles.
Protein names
Recommended name:
Alanine aminotransferase 1Short name:
ALT1Alternative name(s):
Glutamate pyruvate transaminase 1GPT 1
Glutamic--alanine transaminase 1
Glutamic--pyruvic transaminase 1
- RS1063739 (GPT) ??
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Top Gene-Substance Interactions
GPT Interacts with These Diseases
| Disease | Score |
Substances That Increase GPT
| Substances | Interaction | Organism | Category |
Substances That Decrease GPT
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue.
Induction:
By glucocorticoids.
Molecular Function:
Biological Processes:
Drug Bank:
- L-Alanine
- Phenelzine