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  3. GPRC5B

GPRC5B (G protein-coupled receptor class C group 5 member B)

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The Function of GPRC5B

Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

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Protein names

Recommended name:

G-protein coupled receptor family C group 5 member B

Short name:

RAIG-2

Alternative name(s):

A-69G12.1
Retinoic acid-induced gene 2 protein

GPRC5B SNPs

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  1. RS12444979 (GPRC5B) ??

Top Gene-Substance Interactions

Substances That Increase GPRC5B

Substances Interaction Organism Category

Substances That Decrease GPRC5B

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte. According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal chord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach.

Induction:

By all-trans retinoic acid (ATRA).

Caution:

It is uncertain whether Met-1 or Met-9 is the initiator.

Molecular Function:

  • G-Protein Coupled Receptor Activity
  • G-Protein Coupled Receptor Binding
  • Protein Kinase Binding

Biological Processes:

  • Glucose Homeostasis
  • Locomotory Behavior
  • Positive Regulation Of Canonical Wnt Signaling Pathway
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Macrophage Cytokine Production
  • Positive Regulation Of Neuron Differentiation
  • Positive Regulation Of Neuron Projection Development
  • Positive Regulation Of Protein Tyrosine Kinase Activity
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CB1_000307013| EH28_22042| G protein-coupled receptor, class C, group 5, member B| G protein-coupled receptor, family C, group 1, member B| G protein-coupled receptor, family C, group 5, member B| G-protein coupled receptor family C group 5 member B| G-protein coupled receptor family C group 5 member B precursor-like protein| H920_17630| hypothetical protein, clone 2-63| M91_04090| MDA_GLEAN10004480| PAL_GLEAN10009774| PANDA_017968| RAIG2| RAIG-2| Retinoic acid-induced gene 2 protein| retinoic acid responsive gene protein| TREES_T100018413| UY3_11339| Y1Q_025474| gprc5b

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