The Function of GPRC5B
Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
Protein names
Recommended name:
G-protein coupled receptor family C group 5 member BShort name:
RAIG-2Alternative name(s):
A-69G12.1Retinoic acid-induced gene 2 protein
- RS12444979 (GPRC5B) ??
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Top Gene-Substance Interactions
Substances That Increase GPRC5B
Substances | Interaction | Organism | Category |
Substances That Decrease GPRC5B
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte. According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal chord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach.
Induction:
By all-trans retinoic acid (ATRA).
Caution:
It is uncertain whether Met-1 or Met-9 is the initiator.
Molecular Function:
Biological Processes:
- Glucose Homeostasis
- Locomotory Behavior
- Positive Regulation Of Canonical Wnt Signaling Pathway
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Macrophage Cytokine Production
- Positive Regulation Of Neuron Differentiation
- Positive Regulation Of Neuron Projection Development
- Positive Regulation Of Protein Tyrosine Kinase Activity