Summary of GPR98
The Function of GPR98
Receptor that may have an important role in the development of the central nervous system.
Recommended name:G-protein coupled receptor 98
Alternative name(s):Monogenic audiogenic seizure susceptibility protein 1 homolog
Usher syndrome type-2C protein
Very large G-protein coupled receptor 1
Covered on Genetics Home Reference: Usher syndromeFrom NCBI Gene: Febrile seizures, familial, 4Usher syndrome, type 2CFrom UniProt: Febrile seizures, familial, 4 (FEB4): Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. [MIM:604352] Usher syndrome 2C (USH2C): USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses. [MIM:605472]
From NCBI Gene: This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008] From UniProt: Receptor that may have an important role in the development of the central nervous system.
Conditions with Increased Gene Activity
|Condition||Change (log2fold)||Comparison||Species||Experimental variables||Experiment name|
The following transcription factors affect gene expression:
Expressed at low levels in adult tissues.
Isoform 1 is 4 times more abundant than isoform 2 in most tissues tested, despite wide variations in absolute levels of expression. Isoform 3 is expressed at about 1.5 times isoform 1 levels in most tissues examined. In fetal testis, isoform 3 is expressed almost exclusively.
- Cell Surface Receptor Signaling Pathway
- G-Protein Coupled Receptor Signaling Pathway
- Maintenance Of Animal Organ Identity
- Nervous System Development
- Neurological System Process
- Photoreceptor Cell Maintenance
- Sensory Perception Of Light Stimulus
- Sensory Perception Of Sound
- Single Organismal Cell-Cell Adhesion
- Visual Perception