The Function of GPNMB
Could be a melanogenic enzyme.
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Protein names
Recommended name:
Transmembrane glycoprotein NMBAlternative name(s):
Transmembrane glycoprotein HGFIN- RS199347 (GPNMB) ??
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Top Gene-Substance Interactions
GPNMB Interacts with These Diseases
| Disease | Score |
Substances That Increase GPNMB
| Substances | Interaction | Organism | Category |
Substances That Decrease GPNMB
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Up-regulated in various cancer cells, including in glioblastoma multiforme. Expressed in many melanoma cells, as well as in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). Hardly detectable in healthy brain.
Molecular Function:
Biological Processes:
- Bone Mineralization
- Cell Adhesion
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Cytokine Production
- Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
- Negative Regulation Of Neuron Death
- Negative Regulation Of T Cell Proliferation
- Negative Regulation Of Tumor Necrosis Factor Production
- Osteoblast Differentiation
- Positive Chemotaxis
- Positive Regulation Of Cell Migration
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Protein Autophosphorylation
- Positive Regulation Of Protein Phosphorylation
- Regulation Of Angiogenesis
- Regulation Of Tissue Remodeling