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  3. GPNMB

GPNMB (Glycoprotein nmb)

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The Function of GPNMB

Could be a melanogenic enzyme.

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Protein names

Recommended name:

Transmembrane glycoprotein NMB

Alternative name(s):

Transmembrane glycoprotein HGFIN

GPNMB SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS199347 (GPNMB) ??

Top Gene-Substance Interactions

GPNMB Interacts with These Diseases

Disease Score

Substances That Increase GPNMB

Substances Interaction Organism Category

Substances That Decrease GPNMB

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

Up-regulated in various cancer cells, including in glioblastoma multiforme. Expressed in many melanoma cells, as well as in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). Hardly detectable in healthy brain.

Molecular Function:

  • Chemoattractant Activity
  • Heparin Binding
  • Integrin Binding
  • Syndecan Binding

Biological Processes:

  • Bone Mineralization
  • Cell Adhesion
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Cytokine Production
  • Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
  • Negative Regulation Of Neuron Death
  • Negative Regulation Of T Cell Proliferation
  • Negative Regulation Of Tumor Necrosis Factor Production
  • Osteoblast Differentiation
  • Positive Chemotaxis
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Protein Autophosphorylation
  • Positive Regulation Of Protein Phosphorylation
  • Regulation Of Angiogenesis
  • Regulation Of Tissue Remodeling
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_10500| AS27_03418| AS28_05467| Dchil| DC-HIL| dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand| dendritic cell-associated transmembrane protein| glycoprotein nmb-like protein| glycoprotein nonmetastatic melanoma protein B| glycoprotein (transmembrane) nmb| GW7_01301| hematopoietic growth factor inducible neurokinin-1| HGFIN| ipd| iris pigment dispersion| M959_00261| N300_01049| N301_06474| N303_06310| N305_02599| N306_04519| N307_09430| N309_12882| N310_11928| N311_02149| N312_07598| N320_09797| N321_03149| N322_02322| N324_09440| N325_00887| N326_05883| N327_04110| N328_12422| N330_09850| N331_00079| N332_07291| N333_05552| N335_10223| N336_03199| N339_03812| N340_10202| N341_12455| nmb| osteoactivin| PAL_GLEAN10021829| PANDA_010266| Protein QNR-71| qnr-71| QNR-71 protein| transmembrane glycoprotein HGFIN| transmembrane glycoprotein NMB| TREES_T100000330| Y1Q_017522| Y956_04219| Z169_16333| gpnmb

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