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  3. GPC6

GPC6 (Glypican 6)

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Summary of GPC6

The gene codes for a protein, glypican 6. It plays a role in the control of cell growth and cell division [R].

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The Function of GPC6

Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling.

Protein names

Recommended name:

Glypican-6 [Cleaved into: Secreted glypican-6]

GPC6 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11839514 (GPC6) ??
  2. RS143258881 (GPC6) ??
  3. RS1572050 (GPC6) ??
  4. RS190494527 (GPC6) ??
  5. RS319564 (GPC6) ??
  6. RS6492654 (GPC6) ??
  7. RS7985891 (GPC6) ??
  8. RS7995215 (GPC6) ??
  9. RS7998314 (GPC6) ??
  10. RS9301951 (GPC6) ??
  11. RS9561252 (GPC6) ??
  12. RS9561329 (GPC6) ??
  13. RS9561428 (GPC6) ??
  14. RS9584154 (GPC6) ??

Top Gene-Substance Interactions

GPC6 Interacts with These Diseases

Disease Score

Substances That Increase GPC6

Substances Interaction Organism Category

Substances That Decrease GPC6

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Omodysplasia 1From UniProt: Omodysplasia 1 (OMOD1): A rare autosomal recessive skeletal dysplasia characterized by facial dysmorphism and severe congenital micromelia with shortening and distal tapering of the humeri and femora, to give a club-like appearance. Typical facial features include a prominent forehead, frontal bossing, short nose with a depressed broad bridge, short columella, anteverted nostrils, long philtrum, and small chin. [MIM:258315]

     From NCBI Gene: The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. [provided by RefSeq, Jan 2009] From UniProt: Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • HNF-1A
  • p53
  • AhR
  • Arnt
  • HNF-1

Tissue specificity:

Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. Detected in breast cancer cells (at protein level).

Gene Pathways:

  • Metabolism
  • Disease
  • Signal Transduction

Induction:

Expression is induced by NFATC2.

Molecular Function:

  • Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
  • Heparan Sulfate Proteoglycan Binding

Biological Processes:

  • Glycosaminoglycan Biosynthetic Process
  • Glycosaminoglycan Catabolic Process
  • Glycosaminoglycan Metabolic Process
  • Retinoid Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_04044| Anapl_14037| AS27_08771| AS28_12027| D623_10030222| glypican-6| glypican-6 proteoglycan| glypican proteoglycan 6| H920_00764| I79_000406| M91_14142| M959_06846| MDA_GLEAN10019116| N300_06231| N301_00895| N302_02092| N303_12338| N305_12111| N306_13791| N307_07836| N308_03363| N309_09722| N311_09348| N322_04731| N327_13777| N331_01883| N340_04866| OMIMD1| PAL_GLEAN10020396| PANDA_007185| TREES_T100016159| UY3_13102| Y956_11663| Z169_10650| gpc6

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