Summary of GPC6
The gene codes for a protein, glypican 6. It plays a role in the control of cell growth and cell division [R].
The Function of GPC6
Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling.
Protein names
Recommended name:
Glypican-6 [Cleaved into: Secreted glypican-6]- RS11839514 (GPC6) ??
- RS143258881 (GPC6) ??
- RS1572050 (GPC6) ??
- RS190494527 (GPC6) ??
- RS319564 (GPC6) ??
- RS6492654 (GPC6) ??
- RS7985891 (GPC6) ??
- RS7995215 (GPC6) ??
- RS7998314 (GPC6) ??
- RS9301951 (GPC6) ??
- RS9561252 (GPC6) ??
- RS9561329 (GPC6) ??
- RS9561428 (GPC6) ??
- RS9584154 (GPC6) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
GPC6 Interacts with These Diseases
| Disease | Score |
Substances That Increase GPC6
| Substances | Interaction | Organism | Category |
Substances That Decrease GPC6
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Omodysplasia 1From UniProt: Omodysplasia 1 (OMOD1): A rare autosomal recessive skeletal dysplasia characterized by facial dysmorphism and severe congenital micromelia with shortening and distal tapering of the humeri and femora, to give a club-like appearance. Typical facial features include a prominent forehead, frontal bossing, short nose with a depressed broad bridge, short columella, anteverted nostrils, long philtrum, and small chin. [MIM:258315]
From NCBI Gene: The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. [provided by RefSeq, Jan 2009] From UniProt: Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. Detected in breast cancer cells (at protein level).
Gene Pathways:
Induction:
Expression is induced by NFATC2.
Molecular Function:
- Heparan Sulfate Proteoglycan Binding
- Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
Biological Processes:
- Retinoid Metabolic Process
- Glycosaminoglycan Biosynthetic Process
- Glycosaminoglycan Catabolic Process
- Glycosaminoglycan Metabolic Process