The Function of GPC3
Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.
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Protein names
Recommended name:
Glypican-3Short name:
MXR7Alternative name(s):
GTR2-2Intestinal protein OCI-5
- RS7883190 (GPC3) ??
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Top Gene-Substance Interactions
GPC3 Interacts with These Diseases
| Disease | Score |
Substances That Increase GPC3
| Substances | Interaction | Organism | Category |
Substances That Decrease GPC3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in lung, liver and kidney.
Gene Pathways:
Molecular Function:
Biological Processes:
- Retinoid Metabolic Process
- Branching Involved In Ureteric Bud Morphogenesis
- Glycosaminoglycan Biosynthetic Process
- Glycosaminoglycan Catabolic Process
- Anatomical Structure Morphogenesis
- Anterior/Posterior Axis Specification
- Body Morphogenesis
- Glycosaminoglycan Metabolic Process
- Bone Mineralization
- Osteoclast Differentiation
- Lung Development
- Positive Regulation Of Bmp Signaling Pathway
- Embryonic Hindlimb Morphogenesis
- Positive Regulation Of Protein Catabolic Process
- Positive Regulation Of Endocytosis
- Negative Regulation Of Smoothened Signaling Pathway
- Positive Regulation Of Smoothened Signaling Pathway
- Negative Regulation Of Growth
- Positive Regulation Of Glucose Import
- Negative Regulation Of Epithelial Cell Proliferation
- Coronary Vasculature Development
- Mesenchymal Cell Proliferation Involved In Ureteric Bud Development
- Mesonephric Duct Morphogenesis
- Cell Proliferation Involved In Metanephros Development
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway