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  3. GPC3

GPC3 (Glypican 3)

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The Function of GPC3

Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.

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Protein names

Recommended name:

Glypican-3

Short name:

MXR7

Alternative name(s):

GTR2-2
Intestinal protein OCI-5

GPC3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS7883190 (GPC3) ??

Top Gene-Substance Interactions

GPC3 Interacts with These Diseases

Disease Score

Substances That Increase GPC3

Substances Interaction Organism Category

Substances That Decrease GPC3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • C/EBPbeta
  • MEF-2A
  • GATA-1
  • GATA-2

Tissue specificity:

Highly expressed in lung, liver and kidney.

Gene Pathways:

  • Metabolism
  • Disease
  • Signal Transduction

Molecular Function:

  • Heparan Sulfate Proteoglycan Binding
  • Peptidyl-Dipeptidase Inhibitor Activity

Biological Processes:

  • Anatomical Structure Morphogenesis
  • Anterior/Posterior Axis Specification
  • Body Morphogenesis
  • Bone Mineralization
  • Branching Involved In Ureteric Bud Morphogenesis
  • Cell Proliferation Involved In Metanephros Development
  • Coronary Vasculature Development
  • Embryonic Hindlimb Morphogenesis
  • Glycosaminoglycan Biosynthetic Process
  • Glycosaminoglycan Catabolic Process
  • Glycosaminoglycan Metabolic Process
  • Lung Development
  • Mesenchymal Cell Proliferation Involved In Ureteric Bud Development
  • Mesonephric Duct Morphogenesis
  • Negative Regulation Of Canonical Wnt Signaling Pathway
  • Negative Regulation Of Epithelial Cell Proliferation
  • Negative Regulation Of Growth
  • Negative Regulation Of Smoothened Signaling Pathway
  • Osteoclast Differentiation
  • Positive Regulation Of Bmp Signaling Pathway
  • Positive Regulation Of Endocytosis
  • Positive Regulation Of Glucose Import
  • Positive Regulation Of Protein Catabolic Process
  • Positive Regulation Of Smoothened Signaling Pathway
  • Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
  • Retinoid Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13821| CB1_007347009| D623_10019401| defective in Simpson-Golabi-Behmel overgrowth syndrome| dgsx| glypican-3| glypican proteoglycan 3| GTR2-2| H920_19495| heparan sulphate proteoglycan| I79_009708| intestinal protein OCI-5| M91_01679| MDA_GLEAN10005217| MXR7| N306_08671| OCI-5| PAL_GLEAN10004644| PANDA_007331| proteoglycan GPC3| SDYS| secreted glypican-3| sgb| SGBS| SGBS1| TREES_T100013820| UY3_03578| Y1Q_020987| gpc3

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