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  3. GOT1

GOT1 (Glutamic-oxaloacetic transaminase 1)

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The Function of GOT1

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

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Protein names

Recommended name:

Aspartate aminotransferase, cytoplasmic

Alternative name(s):

cAspAT
Cysteine aminotransferase, cytoplasmic
Cysteine transaminase, cytoplasmic
cCAT
Glutamate oxaloacetate transaminase 1
Transaminase A

GOT1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS76850691 (GOT1) ??

Top Gene-Substance Interactions

GOT1 Interacts with These Diseases

Disease Score

Substances That Increase GOT1

Substances Interaction Organism Category

Substances That Decrease GOT1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GATA-1
  • FOXC1
  • MIF-1
  • FOXL1
  • HFH-1

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Disease
  • Alanine, aspartate and glutamate metabolism
  • Arginine and proline metabolism
  • Cysteine and methionine metabolism
  • Metabolism
  • Tyrosine metabolism
  • Phenylalanine metabolism
  • Phenylalanine, tyrosine and tryptophan biosynthesis

Molecular Function:

  • Carboxylic Acid Binding
  • Identical Protein Binding
  • L-Aspartate:2-Oxoglutarate Aminotransferase Activity
  • L-Cysteine:2-Oxoglutarate Aminotransferase Activity
  • L-Phenylalanine:2-Oxoglutarate Aminotransferase Activity
  • Phosphatidylserine Decarboxylase Activity
  • Pyridoxal Phosphate Binding

Biological Processes:

  • 2-Oxoglutarate Metabolic Process
  • Aspartate Biosynthetic Process
  • Aspartate Catabolic Process
  • Aspartate Metabolic Process
  • Cellular Amino Acid Biosynthetic Process
  • Cellular Response To Insulin Stimulus
  • Fatty Acid Homeostasis
  • Gluconeogenesis
  • Glutamate Catabolic Process To 2-Oxoglutarate
  • Glutamate Catabolic Process To Aspartate
  • Glutamate Metabolic Process
  • Glycerol Biosynthetic Process
  • Notch Signaling Pathway
  • Oxaloacetate Metabolic Process
  • Response To Glucocorticoid

Drug Bank:

  • L-Cysteine
  • L-Aspartic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| GIG18| aatc| Anapl_06784| AS27_02658| AS28_07227| ASAT| aspartate aminotransferase| aspartate aminotransferase 1| Aspartate aminotransferase, cytoplasmic| aspartate aminotransferase cytoplasmic-like protein| aspartate aminotransferase, cytoplasmic-like protein| aspartate transaminase 1| Aspat| AST1| ASTQTL1| BEST:GH07823| CASPAT| cCAT| CG8430 gene product from transcript CG8430-RB| CG8430-PA| CG8430-PB| cysteine aminotransferase, cytoplasmic| Cysteine transaminase, cytoplasmic| cytosolic aspartate aminotransferase| Dmel_CG8430| FBgn 1124| Gaspat| Glutamate oxaloacetate transaminase 1| glutamate oxaloacetate transaminase 1, soluble| glutamate oxaloacetic transaminase| glutamic-oxaloacetic transaminase 1, soluble| glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)| Got-1| Got1-PA| Got1-PB| Got2| growth-inhibiting protein 18| GW7_18503| H920_11419| M91_10531| M959_09938| MDA_GLEAN10023416| N300_12536| N301_11546| N302_13542| N303_14159| N305_05490| N306_03501| N307_08736| N309_06964| N310_09548| N311_07398| N312_07918| N320_07668| N321_09285| N322_02584| N324_07855| N325_04987| N326_10422| N327_04806| N328_06260| N329_11870| N330_07184| N331_07234| N332_11008| N333_12895| N334_05503| N335_02056| N336_04708| N339_05992| N340_13250| N341_04822| PAL_GLEAN10018288| PANDA_021267| testis secretory sperm-binding protein Li 196a| transaminase A| TREES_T100012257| UY3_06357| xr406| xr-406 protein| Y1Q_025899| Y956_01462| got1

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