The Function of GOT1
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Protein names
Recommended name:
Aspartate aminotransferase, cytoplasmicAlternative name(s):
cAspATCysteine aminotransferase, cytoplasmic
Cysteine transaminase, cytoplasmic
cCAT
Glutamate oxaloacetate transaminase 1
Transaminase A
- RS76850691 (GOT1) ??
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Top Gene-Substance Interactions
GOT1 Interacts with These Diseases
| Disease | Score |
Substances That Increase GOT1
| Substances | Interaction | Organism | Category |
Substances That Decrease GOT1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- L-Aspartate:2-Oxoglutarate Aminotransferase Activity
- Phosphatidylserine Decarboxylase Activity
- Pyridoxal Phosphate Binding
- Carboxylic Acid Binding
- Identical Protein Binding
- L-Cysteine:2-Oxoglutarate Aminotransferase Activity
- L-Phenylalanine:2-Oxoglutarate Aminotransferase Activity
Biological Processes:
- Gluconeogenesis
- 2-Oxoglutarate Metabolic Process
- Oxaloacetate Metabolic Process
- Glycerol Biosynthetic Process
- Aspartate Metabolic Process
- Aspartate Biosynthetic Process
- Aspartate Catabolic Process
- Glutamate Metabolic Process
- Notch Signaling Pathway
- Cellular Amino Acid Biosynthetic Process
- Glutamate Catabolic Process To Aspartate
- Glutamate Catabolic Process To 2-Oxoglutarate
- Cellular Response To Insulin Stimulus
- Response To Glucocorticoid
- Fatty Acid Homeostasis
Drug Bank:
- L-Cysteine
- L-Aspartic Acid