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  3. GNB4

GNB4 (G protein subunit beta 4)

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The Function of GNB4

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

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GNB4 SNPs

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  1. RS7612445 (GNB4) ??

Top Gene-Substance Interactions

Substances That Increase GNB4

Substances Interaction Organism Category

Substances That Decrease GNB4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • c-Jun
  • deltaCREB
  • MEF-2A
  • GATA-1
  • GATA-2

Tissue specificity:

Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves.

Gene Pathways:

  • Metabolism
  • Signal Transduction
  • Hemostasis
  • Chemokine signaling pathway
  • Glutamatergic synapse
  • Neuronal System
  • Transmembrane transport of small molecules

Molecular Function:

  • Protein Complex Binding
  • Signal Transducer Activity

Biological Processes:

  • Cellular Response To Glucagon Stimulus
  • Protein Folding
  • Substantia Nigra Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| guanine nucleotide binding protein (G protein), beta polypeptide| A306_05760| AS27_14105| AS28_05370| CB1_000693008| CMTD1F| EGK_11879| EH28_14598| G(beta)4| G protein beta-4 subunit| G-protein beta 4 subunit| guanine nucleotide binding protein, beta 4| guanine nucleotide binding protein beta 4 subunit| guanine nucleotide-binding protein, beta-4 subunit| guanine nucleotide binding protein , beta polypeptide 4| guanine nucleotide binding protein (G protein), beta 4| guanine nucleotide binding protein (G protein), beta polypeptide 4| guanine nucleotide-binding protein subunit beta-4| H920_08812| I79_017184| MDA_GLEAN10016654| N300_03240| N301_07767| N302_03717| N303_10321| N305_01819| N306_05031| N307_05297| N308_11714| N309_02415| N321_05461| N322_11831| N324_07244| N325_01377| N326_13027| N327_01987| N328_09356| N329_10464| N333_13372| PAL_GLEAN10012887| PANDA_000240| transducin beta chain 4| UY3_04385| Y1Q_031289| Y956_04965| Z169_12302| gnb4

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