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  3. GNB3

GNB3 (G protein subunit beta 3)

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Summary of GNB3

This gene encodes a beta subunit that belongs to the WD repeat G protein beta family. Beta subunits regulate alpha subunits, signal transduction receptors, and effectors. Polymorphisms of this gene are associated with obesity and high blood pressure (R). 

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The Function of GNB3

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Protein names

Recommended name:

Guanine nucleotide-binding protein G

Short name:

I

Alternative name(s):

S
T
Transducin beta chain 3

GNB3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1129649 (GNB3) ??
  2. RS2301339 (GNB3) ??
  3. RS4963516 (GNB3) ??
  4. RS5442 (GNB3) ??
  5. RS5446 (GNB3) ??

Top Gene-Substance Interactions

GNB3 Interacts with These Diseases

Disease Score

Substances That Increase GNB3

Substances Interaction Organism Category

Substances That Decrease GNB3

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Essential hypertensionNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1H

     From NCBI Gene: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity . This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014] From UniProt: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • CREB
  • deltaCREB

Gene Pathways:

  • Metabolism
  • Signal Transduction
  • Hemostasis
  • Chemokine signaling pathway
  • Glutamatergic synapse
  • Neuronal System
  • Transmembrane transport of small molecules
  • Taste transduction

Molecular Function:

  • Gtpase Activity
  • Gtpase Binding
  • Signal Transducer Activity

Biological Processes:

  • Cellular Response To Glucagon Stimulus
  • G-Protein Coupled Receptor Signaling Pathway
  • Protein Folding
  • Regulation Of Blood Pressure
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| guanine nucleotide binding protein (G protein), beta polypeptide| guanine nucleotide binding protein (G protein), beta polypeptide 3| AS27_05491| AS28_01404| CB1_000289002| CSNB1H| EGK_03291| EH28_17220| Gnb-3| G protein, beta-3 subunit| G protein beta-subunit| GTP-binding protein beta-3 subunit short isoform| GTP-binding regulatory protein beta-3 chain| guanine nucleotide binding protein, beta 3| guanine nucleotide-binding protein, beta-3 subunit| guanine nucleotide binding protein beta polypeptide 3| guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3| Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3| guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3-like protein| guanine nucleotide binding protein (G protein), beta 3| GW7_12121| H920_18381| hypertension associated protein| I79_001412| M959_01765| MDA_GLEAN10016032| N300_14135| N301_07476| N303_15789| N305_07304| N306_14170| N307_10677| N308_11200| N309_14086| N310_09812| N311_12805| N312_02230| N320_01979| N321_13668| N322_11796| N324_07282| N326_09622| N327_06416| N328_04604| N330_04242| N332_09286| N333_00176| N334_01195| N335_02267| N336_05809| N339_09830| N340_09974| PAL_GLEAN10015566| PANDA_011250| transducin beta-3-subunit| transducin beta chain 3| UY3_16430| Y1Q_030373| Y956_11790| gnb3

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