The Function of GNAQ
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).
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Protein names
Recommended name:
Guanine nucleotide-binding protein GAlternative name(s):
qGuanine nucleotide-binding protein alpha-q
- RS4745661 (GNAQ) ??
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Top Gene-Substance Interactions
GNAQ Interacts with These Diseases
| Disease | Score |
Substances That Increase GNAQ
| Substances | Interaction | Organism | Category |
Substances That Decrease GNAQ
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level).
Gene Pathways:
- Metabolism
- Signal Transduction
- Melanogenesis
- Calcium signaling pathway
- Hemostasis
- Pancreatic secretion
- Vascular smooth muscle contraction
- Alzheimer's disease
- Chagas disease (American trypanosomiasis)
- African trypanosomiasis
- Amoebiasis
- Gastric acid secretion
- Glutamatergic synapse
- Long-term depression
- Endocrine and other factor-regulated calcium reabsorption
- GnRH signaling pathway
- Salivary secretion
- Huntington's disease
- Long-term potentiation
Molecular Function:
- Gtpase Activator Activity
- Gtpase Activity
- Gtp Binding
- Metal Ion Binding
- Signal Transducer Activity
- Type 2a Serotonin Receptor Binding
Biological Processes:
- Action Potential
- Activation Of Phospholipase C Activity
- Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
- Blood Coagulation
- Developmental Pigmentation
- Embryonic Digit Morphogenesis
- Entrainment Of Circadian Clock
- Forebrain Neuron Development
- Glutamate Receptor Signaling Pathway
- G-Protein Coupled Acetylcholine Receptor Signaling Pathway
- Heart Development
- Maternal Behavior
- Negative Regulation Of Protein Kinase Activity
- Neuron Remodeling
- Phospholipase C-Activating Dopamine Receptor Signaling Pathway
- Phototransduction, Visible Light
- Platelet Activation
- Post-Embryonic Development
- Protein Stabilization
- Regulation Of Catenin Import Into Nucleus
- Regulation Of Melanocyte Differentiation
- Skeletal System Development