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  3. GNAQ

GNAQ (G protein subunit alpha q)

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The Function of GNAQ

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).

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Protein names

Recommended name:

Guanine nucleotide-binding protein G

Alternative name(s):

q
Guanine nucleotide-binding protein alpha-q

GNAQ SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4745661 (GNAQ) ??

Top Gene-Substance Interactions

GNAQ Interacts with These Diseases

Disease Score

Substances That Increase GNAQ

Substances Interaction Organism Category

Substances That Decrease GNAQ

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1
  • AP-1
  • c-Jun

Tissue specificity:

Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level).

Gene Pathways:

  • Metabolism
  • Signal Transduction
  • Melanogenesis
  • Calcium signaling pathway
  • Hemostasis
  • Pancreatic secretion
  • Vascular smooth muscle contraction
  • Alzheimer's disease
  • Chagas disease (American trypanosomiasis)
  • African trypanosomiasis
  • Amoebiasis
  • Gastric acid secretion
  • Glutamatergic synapse
  • Long-term depression
  • Endocrine and other factor-regulated calcium reabsorption
  • GnRH signaling pathway
  • Salivary secretion
  • Huntington's disease
  • Long-term potentiation

Molecular Function:

  • Gtpase Activator Activity
  • Gtpase Activity
  • Gtp Binding
  • Metal Ion Binding
  • Signal Transducer Activity
  • Type 2a Serotonin Receptor Binding

Biological Processes:

  • Action Potential
  • Activation Of Phospholipase C Activity
  • Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
  • Blood Coagulation
  • Developmental Pigmentation
  • Embryonic Digit Morphogenesis
  • Entrainment Of Circadian Clock
  • Forebrain Neuron Development
  • Glutamate Receptor Signaling Pathway
  • G-Protein Coupled Acetylcholine Receptor Signaling Pathway
  • Heart Development
  • Maternal Behavior
  • Negative Regulation Of Protein Kinase Activity
  • Neuron Remodeling
  • Phospholipase C-Activating Dopamine Receptor Signaling Pathway
  • Phototransduction, Visible Light
  • Platelet Activation
  • Post-Embryonic Development
  • Protein Stabilization
  • Regulation Of Catenin Import Into Nucleus
  • Regulation Of Melanocyte Differentiation
  • Skeletal System Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_02927| AS28_10950| CB1_001144011| CMC1| D623_10034399| Dsk1| Dsk10| g-alpha-q| Galphaq| G alpha q| Galpha q| gaq| gnaqa| gnaq-a| gnaq-b| Gq| GqI| guanine nucleotide-binding protein alpha-q| guanine nucleotide binding protein, alpha q polypeptide| guanine nucleotide binding protein alpha q subunit| guanine nucleotide binding protein (G protein), q polypeptide| guanine nucleotide-binding protein G(q) alpha subunit| Guanine nucleotide-binding protein G(q) subunit alpha| guanine nucleotide binding protein q polypeptide| guanine nucleotide regulatory protein G alpha q| H920_12709| heterotrimeric guanine nucleotide-binding protein alpha q subunit| I79_020584| M91_05529| MDA_GLEAN10017423| N301_12790| N305_03715| N306_02631| N308_12036| N309_07917| N324_00733| N333_04508| PANDA_015011| SWS| TREES_T100013052| UY3_12416| Y956_14665| Z169_08135| gnaq

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