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  3. GLYAT

GLYAT (Glycine-N-acyltransferase)

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The Function of GLYAT

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.

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Protein names

Recommended name:

Glycine N-acyltransferase

Alternative name(s):

Acyl-CoA:glycine N-acyltransferase
AAc
Aralkyl acyl-CoA N-acyltransferase
Aralkyl acyl-CoA:amino acid N-acyltransferase
Benzoyl-coenzyme A:glycine N-acyltransferase
Glycine N-benzoyltransferase
HRP-1(CLP

GLYAT SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11229555 (GLYAT) ??
  2. RS2507838 (GLYAT) ??

Top Gene-Substance Interactions

Substances That Increase GLYAT

Substances Interaction Organism Category

Substances That Decrease GLYAT

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • c-Myb

Tissue specificity:

Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers.

Molecular Function:

  • Glycine N-Acyltransferase Activity
  • Glycine N-Benzoyltransferase Activity
  • Transferase Activity, Transferring Acyl Groups

Biological Processes:

  • Acyl-Coa Metabolic Process
  • Glycine Metabolic Process
  • Monocarboxylic Acid Metabolic Process
  • Response To Toxic Substance
  • Xenobiotic Metabolic Process

Drug Bank:

  • Glycine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

CAT| AAc| ACGNAT| acyl-CoA:glycine N-acyltransferase| aralkyl acyl-CoA:amino acid N-acyltransferase| aralkyl acyl-CoA N-acyltransferase| aralkyl-CoA N-acyltransferase| benzoyl-coenzyme A:glycine N-acyltransferase| EGK_04961| GAT| Glycine N-acyltransferase| glycine N-benzoyltransferase| HRP-1(CLP)| liver regeneration-related protein LRRG067| PAL_GLEAN10000447| glyat

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