The Function of GLYAT
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.
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Protein names
Recommended name:
Glycine N-acyltransferaseAlternative name(s):
Acyl-CoA:glycine N-acyltransferaseAAc
Aralkyl acyl-CoA N-acyltransferase
Aralkyl acyl-CoA:amino acid N-acyltransferase
Benzoyl-coenzyme A:glycine N-acyltransferase
Glycine N-benzoyltransferase
HRP-1(CLP
- RS11229555 (GLYAT) ??
- RS2507838 (GLYAT) ??
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Top Gene-Substance Interactions
Substances That Increase GLYAT
| Substances | Interaction | Organism | Category |
Substances That Decrease GLYAT
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers.
Molecular Function:
- Glycine N-Acyltransferase Activity
- Glycine N-Benzoyltransferase Activity
- Transferase Activity, Transferring Acyl Groups
Biological Processes:
- Acyl-Coa Metabolic Process
- Glycine Metabolic Process
- Monocarboxylic Acid Metabolic Process
- Response To Toxic Substance
- Xenobiotic Metabolic Process