The Function of GFI1
Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.
Protein names
Recommended name:
Zinc finger protein Gfi-1Alternative name(s):
Growth factor independent protein 1Zinc finger protein 163
- RS11164654 (GFI1) ??
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Top Gene-Substance Interactions
Substances That Increase GFI1
| Substances | Interaction | Organism | Category |
Substances That Decrease GFI1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Induction:
Down-regulated by TGFB1.
Molecular Function:
- Metal Ion Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Cellular Response To Lipopolysaccharide
- Myeloid Cell Differentiation
- Negative Regulation Of Calcidiol 1-Monooxygenase Activity
- Negative Regulation Of Neuron Projection Development
- Negative Regulation Of Nf-Kappab Transcription Factor Activity
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Vitamin D Biosynthetic Process
- Positive Regulation Of Interleukin-6-Mediated Signaling Pathway
- Regulation Of Histone H3-K4 Methylation
- Regulation Of Toll-Like Receptor Signaling Pathway
- Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
- Transcription, Dna-Templated
- Viral Process