The Function of GDF10
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
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Protein names
Recommended name:
Growth/differentiation factor 10Short name:
BIPAlternative name(s):
GDF-10Bone morphogenetic protein 3B
BMP-3B
Bone-inducing protein
- RS9421748 (GDF10) ??
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Top Gene-Substance Interactions
Substances That Increase GDF10
| Substances | Interaction | Organism | Category |
Substances That Decrease GDF10
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
Molecular Function:
Biological Processes:
- Skeletal System Development
- Osteoblast Differentiation
- Transforming Growth Factor Beta Receptor Signaling Pathway
- Positive Regulation Of Pathway-Restricted Smad Protein Phosphorylation
- Bmp Signaling Pathway
- Regulation Of Apoptotic Process
- Regulation Of Mapk Cascade
- Fat Cell Differentiation
- Negative Regulation Of Osteoblast Differentiation
- Cell Development
- Smad Protein Signal Transduction