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  3. GCNT1

GCNT1 (Glucosaminyl (N-acetyl) transferase 1, core 2)

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The Function of GCNT1

Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes.

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Protein names

Recommended name:

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Short name:

C2GNT

Alternative name(s):

Core 2-branching enzyme
Core2-GlcNAc-transferase
Core 2 GNT

GCNT1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6560517 (GCNT1) ??

Top Gene-Substance Interactions

GCNT1 Interacts with These Diseases

Disease Score

Substances That Increase GCNT1

Substances Interaction Organism Category

Substances That Decrease GCNT1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Nkx2-5
  • Nkx2-2
  • Meis-1
  • GATA-1

Tissue specificity:

Highly expressed in activated T-lymphocytes and myeloid cells.

Gene Pathways:

  • Metabolic pathways
  • Metabolism of proteins
  • Mucin type O-Glycan biosynthesis

Molecular Function:

  • Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase Activity

Biological Processes:

  • Cell Adhesion Molecule Production
  • Glycoprotein Biosynthetic Process
  • Kidney Morphogenesis
  • Leukocyte Tethering Or Rolling
  • O-Glycan Processing
  • Response To Insulin
  • Tissue Morphogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_07278| Anapl_14431| B130048E03| beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N- acetylglucosaminyltransferase| Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase| beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (Core 2 branching enzyme) (Core2-GlcNAc-transferase) (C2GNT)| beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase-like protein| beta-1,6-N-acetylglucosaminyltransferase| beta1,6 N-acetylglucosaminyltransferase| C2 GlcNAcT| C2GNT| C2GNT1| C2GNT-L| CB1_001144021| core 2 beta-1,6-N-acetylglucosaminyltransferase I| core 2 beta1,6 N-acetylglucosaminyltransferase-I| core 2 branching enzyme| core 2-branching enzyme| core 2 GlcNAc-T| core2-GlcNAc-transferase| core 2 GNT| D623_10034406| EGK_07799| enzymatic glycosylation-regulating| G6NT| glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)| glucosaminyl transferase 1, core 2| IGnT| MDA_GLEAN10017417| NACGT2| NAGCT2| PAL_GLEAN10021107| PANDA_013889| TREES_T100013017| UY3_12422| Y1Q_014595| gcnt1

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