The Function of GCNT1
Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes.
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Protein names
Recommended name:
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferaseShort name:
C2GNTAlternative name(s):
Core 2-branching enzymeCore2-GlcNAc-transferase
Core 2 GNT
- RS6560517 (GCNT1) ??
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Top Gene-Substance Interactions
GCNT1 Interacts with These Diseases
| Disease | Score |
Substances That Increase GCNT1
| Substances | Interaction | Organism | Category |
Substances That Decrease GCNT1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in activated T-lymphocytes and myeloid cells.
Molecular Function:
Biological Processes:
- Glycoprotein Biosynthetic Process
- O-Glycan Processing
- Response To Insulin
- Tissue Morphogenesis
- Leukocyte Tethering Or Rolling
- Cell Adhesion Molecule Production
- Kidney Morphogenesis