Protein names
Recommended name:
Glutamate--cysteine ligase regulatory subunitAlternative name(s):
GCS light chainGamma-ECS regulatory subunit
Gamma-glutamylcysteine synthetase regulatory subunit
Glutamate--cysteine ligase modifier subunit
Top Gene-Substance Interactions
GCLM Interacts with These Diseases
| Disease | Score |
Substances That Increase GCLM
| Substances | Interaction | Organism | Category |
Substances That Decrease GCLM
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
In all tissues examined. Highest levels in skeletal muscle.
Gene Pathways:
Molecular Function:
- Glutamate-Cysteine Ligase Activity
- Enzyme Regulator Activity
- Glutamate-Cysteine Ligase Catalytic Subunit Binding
Biological Processes:
- Sulfur Amino Acid Metabolic Process
- Cysteine Metabolic Process
- Glutamate Metabolic Process
- Glutathione Biosynthetic Process
- Response To Oxidative Stress
- Aging
- Response To Nutrient
- Apoptotic Mitochondrial Changes
- Positive Regulation Of Glutamate-Cysteine Ligase Activity
- Cellular Response To Hepatocyte Growth Factor Stimulus
- Hepatic Stellate Cell Activation
- Negative Regulation Of Neuron Apoptotic Process
- Cellular Response To Fibroblast Growth Factor Stimulus
- Response To Human Chorionic Gonadotropin
- Regulation Of Blood Vessel Size
- Response To Nitrosative Stress
- Regulation Of Mitochondrial Depolarization
- Cellular Response To Glucose Stimulus
- Cellular Response To Follicle-Stimulating Hormone Stimulus
- Cellular Response To Thyroxine Stimulus
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Drug Bank:
- L-Cysteine