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  3. GCLM

GCLM (Glutamate-cysteine ligase modifier subunit)

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Protein names

Recommended name:

Glutamate--cysteine ligase regulatory subunit

Alternative name(s):

GCS light chain
Gamma-ECS regulatory subunit
Gamma-glutamylcysteine synthetase regulatory subunit
Glutamate--cysteine ligase modifier subunit

Top Gene-Substance Interactions

GCLM Interacts with These Diseases

Disease Score

Substances That Increase GCLM

Substances Interaction Organism Category

Substances That Decrease GCLM

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Tissue specificity:

In all tissues examined. Highest levels in skeletal muscle.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Glutathione metabolism

Molecular Function:

  • Enzyme Regulator Activity
  • Glutamate-Cysteine Ligase Activity
  • Glutamate-Cysteine Ligase Catalytic Subunit Binding

Biological Processes:

  • Aging
  • Apoptotic Mitochondrial Changes
  • Cellular Response To Fibroblast Growth Factor Stimulus
  • Cellular Response To Follicle-Stimulating Hormone Stimulus
  • Cellular Response To Glucose Stimulus
  • Cellular Response To Hepatocyte Growth Factor Stimulus
  • Cellular Response To Thyroxine Stimulus
  • Cysteine Metabolic Process
  • Glutamate Metabolic Process
  • Glutathione Biosynthetic Process
  • Hepatic Stellate Cell Activation
  • Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
  • Negative Regulation Of Neuron Apoptotic Process
  • Positive Regulation Of Glutamate-Cysteine Ligase Activity
  • Regulation Of Blood Vessel Size
  • Regulation Of Mitochondrial Depolarization
  • Response To Human Chorionic Gonadotropin
  • Response To Nitrosative Stress
  • Response To Nutrient
  • Response To Oxidative Stress
  • Sulfur Amino Acid Metabolic Process

Drug Bank:

  • L-Cysteine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| box| 4919| A306_13381| Anapl_16805| AS27_06097| AS28_00209| CB1_001428051| CG4919 gene product from transcript CG4919-RB| CG4919-PA| CG4919-PB| D623_10016262| deoxynucleotidyltransferase, terminal, interacting protein 2| Dmel_CG4919| DmGCLM| DmGCSl| DNTTIP2| estrogen receptor binding protein| gamma-ECS regulatory subunit| gamma-Glutamylcysteine synthetase regulatory subunit| Gclm-PA| Gclm-PB| Gcmc| GCSl| GCS light chain| GLCLR| glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory| glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)| glutamate cysteine ligase, modifier subunit| glutamate-cysteine ligase, modifier subunit| glutamate-cysteine ligase modifier subunit delta2 alternative splicing| glutamate-cysteine ligase regulatory protein| glutamate--cysteine ligase regulatory subunit| glutamate--cysteine ligase regulatory subunit-like protein| glutamate-cysteine ligase regulatory subunit-like protein| GSC light chain| H920_00562| I79_022778| M959_13062| MDA_GLEAN10013836| N300_00887| N301_03476| N302_00636| N303_13299| N305_09409| N306_07033| N307_00207| N308_07403| N309_07557| N310_12532| N311_01465| N312_11186| N320_03674| N321_07020| N324_11726| N326_00463| N327_06466| N328_03141| N329_10481| N330_05045| N331_00202| N333_00484| N334_12173| N335_00638| N336_05686| N339_07480| N340_10983| N341_00087| PAL_GLEAN10023980| PANDA_006349| Y956_14036| Z169_02286| gclm

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