Summary of GBP2
This gene encodes a protein that is a GTPase which hydrolyzes GTP (R).
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The Function of GBP2
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
Protein names
Recommended name:
Guanylate-binding protein 2Short name:
GBP-2Alternative name(s):
GTP-binding protein 2HuGBP-2
Guanine nucleotide-binding protein 2
Interferon-induced guanylate-binding protein 2
- RS10922573 (GBP2) ??
- RS6428503 (GBP2) ??
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Top Gene-Substance Interactions
GBP2 Interacts with These Diseases
| Disease | Score |
Substances That Increase GBP2
| Substances | Interaction | Organism | Category |
Substances That Decrease GBP2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By IFNG/IFN-gamma during macrophage activation, and by TNF and IL1B.