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  3. GBP2

GBP2 (Guanylate binding protein 2)

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Summary of GBP2

This gene encodes a protein that is a GTPase which hydrolyzes GTP (R).

0 users want this gene increased, 0 users want it decreased

The Function of GBP2

Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.

Protein names

Recommended name:

Guanylate-binding protein 2

Short name:

GBP-2

Alternative name(s):

GTP-binding protein 2
HuGBP-2
Guanine nucleotide-binding protein 2
Interferon-induced guanylate-binding protein 2

GBP2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10922573 (GBP2) ??
  2. RS6428503 (GBP2) ??

Top Gene-Substance Interactions

GBP2 Interacts with These Diseases

Disease Score

Substances That Increase GBP2

Substances Interaction Organism Category

Substances That Decrease GBP2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT3
  • IRF-1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • AML1a
  • NF-1

Gene Pathways:

  • Immune System

Induction:

By IFNG/IFN-gamma during macrophage activation, and by TNF and IL1B.

Molecular Function:

  • Gtpase Activity
  • Gtp Binding

Biological Processes:

  • Immune Response
  • Interferon-Gamma-Mediated Signaling Pathway
  • Type I Interferon Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| p67| GBP-2| GTP-binding protein 2| guanine nucleotide-binding protein 2| guanylate-binding protein 1| guanylate-binding protein 2| guanylate binding protein 2, interferon-inducible| guanylate nucleotide binding protein 2| Interferon-induced guanylate-binding protein 1| interferon-induced guanylate-binding protein 1-like| interferon-induced guanylate-binding protein 2| isoprenylated 67 kDa protein| mGBP2| mGBP-2| UY3_16469| gbp2

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