The Function of GATA6
Transcriptional activator that regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions.
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Protein names
Recommended name:
Transcription factor GATA-6Alternative name(s):
GATA-binding factor 6Top Gene-Substance Interactions
GATA6 Interacts with These Diseases
| Disease | Score |
Substances That Increase GATA6
| Substances | Interaction | Organism | Category |
Substances That Decrease GATA6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in heart, gut and gut-derived tissues.
Gene Pathways:
Molecular Function:
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
- Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
- Rna Polymerase Ii Transcription Factor Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Chromatin Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Factor Binding
- Zinc Ion Binding
- Protein Kinase Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- In Utero Embryonic Development
- Liver Development
- Outflow Tract Septum Morphogenesis
- Type B Pancreatic Cell Differentiation
- Pancreatic A Cell Differentiation
- Transcription From Rna Polymerase Ii Promoter
- Phospholipid Metabolic Process
- Endodermal Cell Fate Determination
- Blood Coagulation
- Male Gonad Development
- Cardiac Muscle Hypertrophy In Response To Stress
- Positive Regulation Of Bmp Signaling Pathway
- Negative Regulation Of Transforming Growth Factor Beta1 Production
- Negative Regulation Of Transforming Growth Factor Beta2 Production
- Tube Morphogenesis
- Negative Regulation Of Apoptotic Process
- Response To Estrogen
- Cellular Protein Metabolic Process
- Cell Fate Commitment
- Positive Regulation Of Angiogenesis
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Cell Development
- Animal Organ Formation
- Smooth Muscle Cell Differentiation
- Positive Regulation Of Cardioblast Differentiation
- Cardiac Muscle Cell Differentiation
- Positive Regulation Of Cardiac Muscle Cell Proliferation
- Lung Saccule Development
- Clara Cell Differentiation
- Type Ii Pneumocyte Differentiation
- Intestinal Epithelial Cell Differentiation
- Cardiac Vascular Smooth Muscle Cell Differentiation
- Response To Growth Factor
- Positive Regulation Of Cell Cycle Arrest
- Cellular Response To Gonadotropin Stimulus
- Cellular Response To Hypoxia
- Cellular Response To Bmp Stimulus