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  3. GATA6

GATA6 (GATA binding protein 6)

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The Function of GATA6

Transcriptional activator that regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions.

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Protein names

Recommended name:

Transcription factor GATA-6

Alternative name(s):

GATA-binding factor 6

Top Gene-Substance Interactions

GATA6 Interacts with These Diseases

Disease Score

Substances That Increase GATA6

Substances Interaction Organism Category

Substances That Decrease GATA6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Nkx2-5
  • Sp1
  • AREB6
  • GATA-2
  • FOXL1
  • GATA-6

Tissue specificity:

Expressed in heart, gut and gut-derived tissues.

Gene Pathways:

  • Hemostasis

Molecular Function:

  • Chromatin Binding
  • Protein Kinase Binding
  • Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Factor Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Binding
  • Transcription Regulatory Region Dna Binding
  • Zinc Ion Binding

Biological Processes:

  • Animal Organ Formation
  • Blood Coagulation
  • Cardiac Muscle Cell Differentiation
  • Cardiac Muscle Hypertrophy In Response To Stress
  • Cardiac Vascular Smooth Muscle Cell Differentiation
  • Cell Development
  • Cell Fate Commitment
  • Cellular Protein Metabolic Process
  • Cellular Response To Bmp Stimulus
  • Cellular Response To Gonadotropin Stimulus
  • Cellular Response To Hypoxia
  • Clara Cell Differentiation
  • Endodermal Cell Fate Determination
  • Intestinal Epithelial Cell Differentiation
  • In Utero Embryonic Development
  • Liver Development
  • Lung Saccule Development
  • Male Gonad Development
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Transforming Growth Factor Beta1 Production
  • Negative Regulation Of Transforming Growth Factor Beta2 Production
  • Outflow Tract Septum Morphogenesis
  • Pancreatic A Cell Differentiation
  • Phospholipid Metabolic Process
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Bmp Signaling Pathway
  • Positive Regulation Of Cardiac Muscle Cell Proliferation
  • Positive Regulation Of Cardioblast Differentiation
  • Positive Regulation Of Cell Cycle Arrest
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Response To Estrogen
  • Response To Growth Factor
  • Smooth Muscle Cell Differentiation
  • Transcription From Rna Polymerase Ii Promoter
  • Tube Morphogenesis
  • Type B Pancreatic Cell Differentiation
  • Type Ii Pneumocyte Differentiation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| DNA-binding protein GATA-GT2| GATA-5| A306_05354| AS27_05889| AS28_00765| D623_10034225| GATA-6| gata6a| gata6-a| gata6b| gata6-b| GATA-6 transcription factor| GATA-binding factor 6| M91_00542| MDA_GLEAN10025315| N301_10816| N303_04714| N306_12260| N307_07583| PAL_GLEAN10023164| pnr| tGata6| transcription factor GATA6| transcription factor GATA-6| transcription factor GATA-6-like protein| UY3_04405| XGATA6| XGATA-6| Y1Q_012155| Y956_04642| zinc-finger transcription factor Gata6| gata6

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