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  3. GART

GART (Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase)

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Protein names

Recommended name:

Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

Short name:

GARS

Alternative name(s):

Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
5'-phosphoribosylglycinamide transformylase
GAR transformylase
GART

Top Gene-Substance Interactions

GART Interacts with These Diseases

Disease Score

Substances That Increase GART

Substances Interaction Organism Category

Substances That Decrease GART

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO3
  • FOXO3a
  • CUTL1
  • STAT5A
  • Meis-1
  • FOXO3b

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Purine metabolism
  • One carbon pool by folate
  • Metabolism

Molecular Function:

  • Atp Binding
  • Metal Ion Binding
  • Phosphoribosylamine-Glycine Ligase Activity
  • Phosphoribosylformylglycinamidine Cyclo-Ligase Activity
  • Phosphoribosylglycinamide Formyltransferase Activity

Biological Processes:

  • 'De Novo' Imp Biosynthetic Process
  • Brainstem Development
  • Cerebellum Development
  • Cerebral Cortex Development
  • Glycine Metabolic Process
  • Purine Nucleobase Biosynthetic Process
  • Purine Ribonucleoside Monophosphate Biosynthetic Process
  • Response To Inorganic Substance
  • Response To Organic Substance
  • Tetrahydrofolate Biosynthetic Process

Drug Bank:

  • Pemetrexed
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ade3| AIRS| aminoimidazole ribonucleotide synthetase| Anapl_04532| AS28_02913| CB1_000995038| Gaps| GARS| gars-airs-gart| GARS-AIRS-GART protein| GART-A| GARTF| glycinamide ribonucleotide formyltransferase| glycinamide ribonucleotide synthetase| glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide formyltransferase| glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase| GW7_08737| I79_000830| M91_17699| M959_06971| MDA_GLEAN10011990| N300_07297| N301_04789| N302_03360| N303_13716| N305_12145| N306_05446| N307_12710| N308_11312| N310_04419| N311_00685| N312_11621| N320_00622| N321_05970| N324_02437| N328_06859| N330_02881| N331_02839| N332_02705| N333_01256| N334_08560| N335_14384| N336_00678| N339_05329| PAIS| PAL_GLEAN10025743| PANDA_008270| PGFT| phosphoribosylglycinamide formyltransferase| phosphoribosylglycinamide formyltransferase, phosphoribosylglyci| phosphoribosylglycinamide synthetase| phosphoribosylglycinamide transformylase| Prgs| PUR2| Trifunctional purine biosynthetic protein adenosine-3| trifunctional purine biosynthetic protein adenosine-3-like| Trifunctional purine biosynthetic protein adenosine-3-like protein| UY3_10596| Y956_04387| gart

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