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  3. GAP43

GAP43 (Growth associated protein 43)

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The Function of GAP43

This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

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Protein names

Recommended name:

Neuromodulin

Alternative name(s):

Axonal membrane protein GAP-43
Growth-associated protein 43
Neural phosphoprotein B-50
pp46

GAP43 SNPs

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  1. RS16823858 (GAP43) ??

Top Gene-Substance Interactions

GAP43 Interacts with These Diseases

Disease Score

Substances That Increase GAP43

Substances Interaction Organism Category

Substances That Decrease GAP43

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • CREB
  • deltaCREB
  • Pax-6
  • C/EBPbeta

Molecular Function:

  • Lysophosphatidic Acid Binding
  • Phosphatidylinositol Phosphate Binding
  • Phosphatidylserine Binding

Biological Processes:

  • Axon Choice Point Recognition
  • Axon Development
  • Cell Fate Commitment
  • Glial Cell Differentiation
  • Protein Kinase C-Activating G-Protein Coupled Receptor Signaling Pathway
  • Regulation Of Filopodium Assembly
  • Regulation Of Growth
  • Response To Wounding
  • Tissue Regeneration
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_09798| AS28_01489| Axonal membrane protein GAP-43| B-50| Basp2| brain abundant, membrane attached signal protein 2| calmodulin-binding protein P-57| CB1_000268001| D623_10031769| EGK_11312| gap| GAP-43| gap43-a| gap43-b| growth accentuating protein 43| Growth-associated protein 43| GW7_08236| I79_010877| M91_09193| M959_12451| N300_01220| N301_03205| N302_08029| N303_06911| N305_06264| N306_09915| N307_06647| N308_09797| N309_11243| N310_00591| N311_03916| N312_13136| N320_03330| N321_12888| N324_00162| N325_12695| N326_06576| N330_06269| N332_07711| N333_01598| N334_04604| N335_10699| N336_10358| N340_09642| N341_10679| nerve growth-related peptide GAP43| neural phosphoprotein B-50| neuromodulin| neuromodulin-like protein| neuron growth-associated protein 43| PAL_GLEAN10013400| PANDA_011046| PP46| protein F1| QtrA-13071| Y1Q_011453| Y956_09400| Z169_07598| gap43

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