The Function of GAP43
This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
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Protein names
Recommended name:
NeuromodulinAlternative name(s):
Axonal membrane protein GAP-43Growth-associated protein 43
Neural phosphoprotein B-50
pp46
- RS16823858 (GAP43) ??
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Top Gene-Substance Interactions
GAP43 Interacts with These Diseases
| Disease | Score |
Substances That Increase GAP43
| Substances | Interaction | Organism | Category |
Substances That Decrease GAP43
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Axon Choice Point Recognition
- Axon Development
- Cell Fate Commitment
- Glial Cell Differentiation
- Protein Kinase C-Activating G-Protein Coupled Receptor Signaling Pathway
- Regulation Of Filopodium Assembly
- Regulation Of Growth
- Response To Wounding
- Tissue Regeneration