Summary of GABRB2
This gene is related to GABA, which is the major inhibitory neurotransmitter in the brain (R).
The Function of GABRB2
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Protein names
Recommended name:
Gamma-aminobutyric acid receptor subunit beta-2Short name:
GABA(A- RS164368 (GABRB2) ??
- RS1816071 (GABRB2) ??
- RS6556547 (GABRB2) ??
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Top Gene-Substance Interactions
GABRB2 Interacts with These Diseases
| Disease | Score |
Substances That Increase GABRB2
| Substances | Interaction | Organism | Category |
Substances That Decrease GABRB2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
Gene Pathways:
Molecular Function:
- Gaba-A Receptor Activity
- Inhibitory Extracellular Ligand-Gated Ion Channel Activity
- Chloride Channel Activity
Biological Processes:
- Transport
- Gamma-Aminobutyric Acid Signaling Pathway
- Chemical Synaptic Transmission
- Sensory Perception Of Sound
- Ion Transmembrane Transport
- Negative Regulation Of Neuron Apoptotic Process
- Synaptic Transmission, Gabaergic
- Inner Ear Receptor Cell Development
- Innervation
- Cellular Response To Histamine
- Cochlea Development
- Chloride Transmembrane Transport
Drug Bank:
- Butabarbital
- Clorazepate
- Ergoloid Mesylate
- Ginkgo Biloba
- Adinazolam
- Alprazolam
- Bromazepam
- Butalbital
- Chlordiazepoxide
- Cinolazepam
- Clonazepam
- Clotiazepam
- Desflurane
- Diazepam
- Estazolam
- Eszopiclone
- Ethanol
- Ethchlorvynol
- Etomidate
- Flumazenil
- Flurazepam
- Fospropofol
- Glutethimide
- Halazepam
- Isoflurane
- Lorazepam
- Meprobamate
- Methoxyflurane
- Midazolam
- Nitrazepam
- Olanzapine
- Oxazepam
- Prazepam
- Primidone
- Propofol
- Quazepam
- Sevoflurane
- Temazepam
- Topiramate
- Triazolam
- Acamprosate
- Amoxapine
- Clobazam
- Enflurane
- Fludiazepam
- Halothane
- Methyprylon
- Pentobarbital
- Talbutal