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  3. GABRB2

GABRB2 (Gamma-aminobutyric acid type A receptor beta2 subunit)

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Summary of GABRB2

This gene is related to GABA, which is the major inhibitory neurotransmitter in the brain (R).

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The Function of GABRB2

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

Protein names

Recommended name:

Gamma-aminobutyric acid receptor subunit beta-2

Short name:

GABA(A

GABRB2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS164368 (GABRB2) ??
  2. RS1816071 (GABRB2) ??
  3. RS6556547 (GABRB2) ??

Top Gene-Substance Interactions

GABRB2 Interacts with These Diseases

Disease Score

Substances That Increase GABRB2

Substances Interaction Organism Category

Substances That Decrease GABRB2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • RORalpha2
  • STAT3
  • STAT1beta
  • STAT2
  • STAT4
  • AREB6
  • E47
  • Hand1

Tissue specificity:

Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Neuronal System
  • Transmembrane transport of small molecules

Molecular Function:

  • Chloride Channel Activity
  • Gaba-A Receptor Activity
  • Inhibitory Extracellular Ligand-Gated Ion Channel Activity

Biological Processes:

  • Cellular Response To Histamine
  • Chemical Synaptic Transmission
  • Chloride Transmembrane Transport
  • Cochlea Development
  • Gamma-Aminobutyric Acid Signaling Pathway
  • Inner Ear Receptor Cell Development
  • Innervation
  • Ion Transmembrane Transport
  • Negative Regulation Of Neuron Apoptotic Process
  • Sensory Perception Of Sound
  • Synaptic Transmission, Gabaergic
  • Transport

Drug Bank:

  • Butabarbital
  • Clorazepate
  • Ergoloid Mesylate
  • Ginkgo Biloba
  • Adinazolam
  • Alprazolam
  • Bromazepam
  • Butalbital
  • Chlordiazepoxide
  • Cinolazepam
  • Clonazepam
  • Clotiazepam
  • Desflurane
  • Diazepam
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Ethchlorvynol
  • Etomidate
  • Flumazenil
  • Flurazepam
  • Fospropofol
  • Glutethimide
  • Halazepam
  • Isoflurane
  • Lorazepam
  • Meprobamate
  • Methoxyflurane
  • Midazolam
  • Nitrazepam
  • Olanzapine
  • Oxazepam
  • Prazepam
  • Primidone
  • Propofol
  • Quazepam
  • Sevoflurane
  • Temazepam
  • Topiramate
  • Triazolam
  • Acamprosate
  • Amoxapine
  • Clobazam
  • Enflurane
  • Fludiazepam
  • Halothane
  • Methyprylon
  • Pentobarbital
  • Talbutal
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_14451| AS27_11863| AS28_10292| CB1_047321015| EGK_17097| EH28_16247| fj59e04| gabaabeta2| GABA-A beta 2 subunit| GABA A receptor beta 2 subunit| GABA-A receptor, beta-2 subunit| GABAA receptor betaZ2| GABA(A) receptor subunit beta-2| GABARB| GABA receptor subunit beta-2 protein| Gabrab2| Gabrb-2| gamma-aminobutyric acid A receptor beta 2| gamma-aminobutyric acid A receptor, beta 2| gamma-aminobutyric acid A receptor beta 2 subunit| gamma-aminobutyric acidA receptor beta 2 subunit| gamma-aminobutyric acid A receptor, subunit beta 2| gamma-aminobutyric acid (GABA) A receptor, beta 2| gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2| gamma-aminobutyric acid (GABA) A receptor, subunit beta 2| Gamma-aminobutyric acid receptor beta 2| gamma-aminobutyric acid receptor beta-2 subunit| Gamma-aminobutyric acid receptor subunit beta-2| gamma-aminobutyric acid receptor subunit beta-2-like protein| gamma-aminobutyric acid type A receptor beta 2 subunit| GARB2| GW7_13529| H920_04495| M959_08289| MDA_GLEAN10025749| N300_13065| N301_05006| N303_08876| N305_08700| N306_01335| N307_13825| N308_09091| N322_02210| N329_03070| N333_01394| N335_13613| N339_03586| PAL_GLEAN10018845| PANDA_000325| TREES_T100004769| UY3_18174| Y1Q_028931| Y956_14121| gabrb2

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