Summary of GABRB1
This gene is related to GABA, which is the major inhibitory neurotransmitter in the brain (R).
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The Function of GABRB1
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Protein names
Recommended name:
Gamma-aminobutyric acid receptor subunit beta-1Short name:
GABA(A- RS6289 (GABRB1) ??
- RS728293 (GABRB1) ??
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Top Gene-Substance Interactions
GABRB1 Interacts with These Diseases
| Disease | Score |
Substances That Increase GABRB1
| Substances | Interaction | Organism | Category |
Substances That Decrease GABRB1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Transport
- Ion Transport
- Signal Transduction
- Response To Toxic Substance
- Central Nervous System Neuron Development
- Response To Progesterone
- Ion Transmembrane Transport
- Ovulation Cycle
- Cellular Response To Histamine
- Chloride Transmembrane Transport
Drug Bank:
- Butabarbital
- Clorazepate
- Ergoloid Mesylate
- Gamma Hydroxybutyric Acid
- Alprazolam
- Amoxapine
- Bromazepam
- Butalbital
- Cinolazepam
- Clobazam
- Clonazepam
- Clotiazepam
- Desflurane
- Enflurane
- Estazolam
- Eszopiclone
- Ethanol
- Etomidate
- Fludiazepam
- Flumazenil
- Flurazepam
- Glutethimide
- Halazepam
- Isoflurane
- Ketazolam
- Lindane
- Lorazepam
- Methoxyflurane
- Methyprylon
- Midazolam
- Nitrazepam
- Olanzapine
- Pentobarbital
- Prazepam
- Primidone
- Propofol
- Quazepam
- Talbutal
- Temazepam
- Topiramate
- Triazolam
- Acamprosate
- Adinazolam
- Chlordiazepoxide
- Diazepam
- Ethchlorvynol
- Halothane
- Meprobamate
- Oxazepam
- Sevoflurane