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  3. GABRB1

GABRB1 (Gamma-aminobutyric acid type A receptor beta1 subunit)

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Summary of GABRB1

This gene is related to GABA, which is the major inhibitory neurotransmitter in the brain (R).

0 users want this gene increased, 0 users want it decreased

The Function of GABRB1

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

Protein names

Recommended name:

Gamma-aminobutyric acid receptor subunit beta-1

Short name:

GABA(A

GABRB1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6289 (GABRB1) ??
  2. RS728293 (GABRB1) ??

Top Gene-Substance Interactions

GABRB1 Interacts with These Diseases

Disease Score

Substances That Increase GABRB1

Substances Interaction Organism Category

Substances That Decrease GABRB1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • AREB6
  • NF-kappaB2
  • RelA

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Neuronal System
  • Transmembrane transport of small molecules

Molecular Function:

  • Gaba-A Receptor Activity
  • Gaba-Gated Chloride Ion Channel Activity
  • Ligand-Gated Ion Channel Activity

Biological Processes:

  • Cellular Response To Histamine
  • Central Nervous System Neuron Development
  • Chloride Transmembrane Transport
  • Ion Transmembrane Transport
  • Ion Transport
  • Ovulation Cycle
  • Response To Progesterone
  • Response To Toxic Substance
  • Signal Transduction
  • Transport

Drug Bank:

  • Butabarbital
  • Clorazepate
  • Ergoloid Mesylate
  • Gamma Hydroxybutyric Acid
  • Alprazolam
  • Amoxapine
  • Bromazepam
  • Butalbital
  • Cinolazepam
  • Clobazam
  • Clonazepam
  • Clotiazepam
  • Desflurane
  • Enflurane
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Etomidate
  • Fludiazepam
  • Flumazenil
  • Flurazepam
  • Glutethimide
  • Halazepam
  • Isoflurane
  • Ketazolam
  • Lindane
  • Lorazepam
  • Methoxyflurane
  • Methyprylon
  • Midazolam
  • Nitrazepam
  • Olanzapine
  • Pentobarbital
  • Prazepam
  • Primidone
  • Propofol
  • Quazepam
  • Talbutal
  • Temazepam
  • Topiramate
  • Triazolam
  • Acamprosate
  • Adinazolam
  • Chlordiazepoxide
  • Diazepam
  • Ethchlorvynol
  • Halothane
  • Meprobamate
  • Oxazepam
  • Sevoflurane
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_08961| Anapl_14097| AS27_00279| AS28_04970| CB1_000854027| D623_10022847| EGK_15693| GABA(A) receptor, beta 1| GABA(A) receptor subunit beta-1| Gabrb-1| gamma-aminobutyric acid A receptor beta 1| gamma-aminobutyric acid (GABA) A receptor, beta 1| gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1| gamma-aminobutyric acid (GABA) A receptor, subunit beta 1| Gamma-aminobutyric acid receptor beta 1| Gamma-aminobutyric acid receptor subunit beta-1| gamma-aminobutyric acid type A receptor beta 1 subunit| GARB1| H920_12119| I79_015509| M91_15791| M959_04214| MDA_GLEAN10013172| N301_01889| N302_04078| N303_07305| N305_05123| N308_10786| N309_08847| N324_11931| N325_10426| N330_04167| N334_10973| N335_10810| N336_09310| N340_04863| N341_02331| PAL_GLEAN10016074| PANDA_005229| TREES_T100002554| UY3_17752| Y1Q_030614| Y956_08100| Z169_12645| gabrb1

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