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  3. GABRA4

GABRA4 (Gamma-aminobutyric acid type A receptor alpha4 subunit)

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Summary of GABRA4

It is an inhibitory neurotransmitter in the brain. The gene codes for subunit alpha-4. It increases the chances of autism when it interacts with subunit gamma-aminobutyric acid receptor beta-1 (GABRB1) [R].

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The Function of GABRA4

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Protein names

Recommended name:

Gamma-aminobutyric acid receptor subunit alpha-4

Short name:

GABA(A

GABRA4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2055942 (GABRA4) ??
  2. RS2229940 (GABRA4) ??
  3. RS2280073 (GABRA4) ??
  4. RS6447514 (GABRA4) ??

Top Gene-Substance Interactions

GABRA4 Interacts with These Diseases

Disease Score

Substances That Increase GABRA4

Substances Interaction Organism Category

Substances That Decrease GABRA4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Neuronal System
  • Transmembrane transport of small molecules

Induction:

The alpha4 beta2 gamma 2L receptor is not repressed by diazepam.

Molecular Function:

  • Benzodiazepine Receptor Activity
  • Chloride Channel Activity
  • Extracellular Ligand-Gated Ion Channel Activity
  • Gaba-A Receptor Activity

Biological Processes:

  • Central Nervous System Development
  • Gamma-Aminobutyric Acid Signaling Pathway
  • Ion Transmembrane Transport
  • Transport

Drug Bank:

  • Aprobarbital
  • Butabarbital
  • Butethal
  • Clorazepate
  • Ergoloid Mesylate
  • Methylphenobarbital
  • Amobarbital
  • Amoxapine
  • Bromazepam
  • Butalbital
  • Clobazam
  • Clonazepam
  • Desflurane
  • Diazepam
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Ethchlorvynol
  • Etomidate
  • Flumazenil
  • Flurazepam
  • Glutethimide
  • Halazepam
  • Halothane
  • Heptabarbital
  • Hexobarbital
  • Lorazepam
  • Meprobamate
  • Methoxyflurane
  • Methyprylon
  • Midazolam
  • Olanzapine
  • Oxazepam
  • Pentobarbital
  • Prazepam
  • Primidone
  • Quazepam
  • Secobarbital
  • Sevoflurane
  • Talbutal
  • Thiopental
  • Topiramate
  • Triazolam
  • Acamprosate
  • Alprazolam
  • Chlordiazepoxide
  • Enflurane
  • Flunitrazepam
  • Isoflurane
  • Nitrazepam
  • Propofol
  • Temazepam
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_14098| AS27_00278| AS28_04971| CB1_000668002| D623_10022846| EGK_15692| GABA(A) receptor, alpha 4| GABA-A receptor alpha-4 subunit| GABA(A) receptor subunit alpha-4| Gabra-4| gamma-aminobutyric acid A receptor alpha 4| gamma-aminobutyric acid A receptor, alpha 4| gamma-aminobutyric acid (GABA) A receptor, alpha 4| gamma-aminobutyric acid (GABA) A receptor, alpha 6| gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4| gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4| gamma-aminobutyric acid receptor subunit alpha-4| gamma-aminobutyric acid receptor subunit alpha-4-like| GW7_21819| I79_015507| M959_04215| MDA_GLEAN10013167| N300_04100| N301_01886| N302_04077| N303_07304| N305_00383| N306_01292| N307_07074| N308_10787| N309_08846| N310_01413| N311_07667| N312_01978| N327_00686| N329_07506| N330_13166| N331_01305| N332_04375| N335_14436| N336_03811| PAL_GLEAN10016073| PANDA_005231| Y1Q_030615| Y956_08099| Z169_12644| gabra4

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