Summary of GABRA4
It is an inhibitory neurotransmitter in the brain. The gene codes for subunit alpha-4. It increases the chances of autism when it interacts with subunit gamma-aminobutyric acid receptor beta-1 (GABRB1) [R].
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The Function of GABRA4
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Protein names
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-4Short name:
GABA(A- RS2055942 (GABRA4) ??
- RS2229940 (GABRA4) ??
- RS2280073 (GABRA4) ??
- RS6447514 (GABRA4) ??
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Top Gene-Substance Interactions
GABRA4 Interacts with These Diseases
| Disease | Score |
Substances That Increase GABRA4
| Substances | Interaction | Organism | Category |
Substances That Decrease GABRA4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
The alpha4 beta2 gamma 2L receptor is not repressed by diazepam.
Molecular Function:
- Benzodiazepine Receptor Activity
- Chloride Channel Activity
- Extracellular Ligand-Gated Ion Channel Activity
- Gaba-A Receptor Activity
Biological Processes:
- Central Nervous System Development
- Gamma-Aminobutyric Acid Signaling Pathway
- Ion Transmembrane Transport
- Transport
Drug Bank:
- Aprobarbital
- Butabarbital
- Butethal
- Clorazepate
- Ergoloid Mesylate
- Methylphenobarbital
- Amobarbital
- Amoxapine
- Bromazepam
- Butalbital
- Clobazam
- Clonazepam
- Desflurane
- Diazepam
- Estazolam
- Eszopiclone
- Ethanol
- Ethchlorvynol
- Etomidate
- Flumazenil
- Flurazepam
- Glutethimide
- Halazepam
- Halothane
- Heptabarbital
- Hexobarbital
- Lorazepam
- Meprobamate
- Methoxyflurane
- Methyprylon
- Midazolam
- Olanzapine
- Oxazepam
- Pentobarbital
- Prazepam
- Primidone
- Quazepam
- Secobarbital
- Sevoflurane
- Talbutal
- Thiopental
- Topiramate
- Triazolam
- Acamprosate
- Alprazolam
- Chlordiazepoxide
- Enflurane
- Flunitrazepam
- Isoflurane
- Nitrazepam
- Propofol
- Temazepam