The Function of GABRA1
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
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Protein names
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-1Short name:
GABA(ATop Gene-Substance Interactions
GABRA1 Interacts with These Diseases
| Disease | Score |
Substances That Increase GABRA1
| Substances | Interaction | Organism | Category |
Substances That Decrease GABRA1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Transport
- Gamma-Aminobutyric Acid Signaling Pathway
- Ion Transmembrane Transport
- Synaptic Transmission, Gabaergic
- Cellular Response To Histamine
- Chloride Transmembrane Transport
Drug Bank:
- Aprobarbital
- Butabarbital
- Butethal
- Clorazepate
- Ergoloid Mesylate
- Ginkgo Biloba
- Methylphenobarbital
- Quinidine Barbiturate
- Adinazolam
- Alprazolam
- Amobarbital
- Bromazepam
- Butalbital
- Chlordiazepoxide
- Cinolazepam
- Clonazepam
- Clotiazepam
- Desflurane
- Diazepam
- Estazolam
- Eszopiclone
- Ethanol
- Ethchlorvynol
- Etomidate
- Flumazenil
- Flurazepam
- Glutethimide
- Halazepam
- Halothane
- Hexobarbital
- Isoflurane
- Ketazolam
- Lorazepam
- Meprobamate
- Methoxyflurane
- Methyprylon
- Midazolam
- Nitrazepam
- Olanzapine
- Pentobarbital
- Phenobarbital
- Prazepam
- Primidone
- Progabide
- Propofol
- Secobarbital
- Sevoflurane
- Talbutal
- Temazepam
- Thiopental
- Topiramate
- Triazolam
- Zaleplon
- Zopiclone
- Acamprosate
- Amoxapine
- Clobazam
- Enflurane
- Fludiazepam
- Heptabarbital
- Methohexital
- Oxazepam
- Quazepam
- Thiamylal
- Zolpidem