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  3. GABRA1

GABRA1 (Gamma-aminobutyric acid type A receptor alpha1 subunit)

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The Function of GABRA1

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

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Protein names

Recommended name:

Gamma-aminobutyric acid receptor subunit alpha-1

Short name:

GABA(A

Top Gene-Substance Interactions

GABRA1 Interacts with These Diseases

Disease Score

Substances That Increase GABRA1

Substances Interaction Organism Category

Substances That Decrease GABRA1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Neuronal System
  • Transmembrane transport of small molecules

Molecular Function:

  • Drug Binding
  • Gaba-A Receptor Activity
  • Gaba-Gated Chloride Ion Channel Activity

Biological Processes:

  • Cellular Response To Histamine
  • Chloride Transmembrane Transport
  • Gamma-Aminobutyric Acid Signaling Pathway
  • Ion Transmembrane Transport
  • Synaptic Transmission, Gabaergic
  • Transport

Drug Bank:

  • Aprobarbital
  • Butabarbital
  • Butethal
  • Clorazepate
  • Ergoloid Mesylate
  • Ginkgo Biloba
  • Methylphenobarbital
  • Quinidine Barbiturate
  • Adinazolam
  • Alprazolam
  • Amobarbital
  • Bromazepam
  • Butalbital
  • Chlordiazepoxide
  • Cinolazepam
  • Clonazepam
  • Clotiazepam
  • Desflurane
  • Diazepam
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Ethchlorvynol
  • Etomidate
  • Flumazenil
  • Flurazepam
  • Glutethimide
  • Halazepam
  • Halothane
  • Hexobarbital
  • Isoflurane
  • Ketazolam
  • Lorazepam
  • Meprobamate
  • Methoxyflurane
  • Methyprylon
  • Midazolam
  • Nitrazepam
  • Olanzapine
  • Pentobarbital
  • Phenobarbital
  • Prazepam
  • Primidone
  • Progabide
  • Propofol
  • Secobarbital
  • Sevoflurane
  • Talbutal
  • Temazepam
  • Thiopental
  • Topiramate
  • Triazolam
  • Zaleplon
  • Zopiclone
  • Acamprosate
  • Amoxapine
  • Clobazam
  • Enflurane
  • Fludiazepam
  • Heptabarbital
  • Methohexital
  • Oxazepam
  • Quazepam
  • Thiamylal
  • Zolpidem
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| EJM| A306_14625| Anapl_14454| AS27_11861| AS28_10294| CB1_047321013| ECA4| EGK_17100| EIEE19| EJM5| GABAA alpha 1| GABA-A alpha 1 subunit| GABAAR alpha1| GABA(A) receptor, alpha 1| GABA-A receptor alpha-1 subunit| GABA-A receptor subunit alpha 1| GABA(A) receptor subunit alpha-1| GABA receptor subunit alpha-1 protein| Gabra-1| GABRA2| gamma-aminobutyric acid A receptor, alpha 1| gamma-aminobutyric acid A receptor alpha 1| gamma-aminobutyric acid A receptor, alpha 1| gamma-aminobutyric acid A receptor alpha 1 variant 1| gamma-aminobutyric acid A receptor alpha 1 variant 2| gamma-aminobutyric acid A receptor alpha 1 variant 3| gamma-aminobutyric acid A receptor alpha 1 variant 4| gamma-aminobutyric acid A receptor subunit alpha1| gamma-aminobutyric acid (GABA) A receptor, alpha 1| gamma-aminobutyric acid (GABA) A receptor, alpha 2| gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1| gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1| gamma-aminobutyric acid receptor subunit alpha-1| gamma-aminobutyric acid receptor subunit alpha-1-like| I79_017787| M959_08287| MDA_GLEAN10025751| N300_13063| N301_05004| N302_03669| N303_08878| N305_08698| N306_12706| N307_00707| N311_04812| N312_03562| N320_04717| N321_04726| N322_08653| N324_04178| N325_05604| N327_01253| N328_07199| N329_06112| N331_04586| N332_07328| N333_09419| N335_12727| N336_10403| N339_08904| N340_01278| N341_00448| PAL_GLEAN10018847| PANDA_000328| TREES_T100004767| UY3_18176| Y1Q_028929| Y956_14123| Z169_04281| gabra1

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