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  3. GABBR1

GABBR1 (Gamma-aminobutyric acid type B receptor subunit 1)

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The Function of GABBR1

Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

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Protein names

Recommended name:

Gamma-aminobutyric acid type B receptor subunit 1

Alternative name(s):

GABA-B receptor 1
GABA-B-R1
GABA-BR1
GABABR1
Gb1

Top Gene-Substance Interactions

GABBR1 Interacts with These Diseases

Disease Score

Substances That Increase GABBR1

Substances Interaction Organism Category

Substances That Decrease GABBR1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • Egr-1
  • CREB
  • deltaCREB

Tissue specificity:

Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Neuronal System

Molecular Function:

  • G-Protein Coupled Gaba Receptor Activity

Biological Processes:

  • Adenylate Cyclase-Inhibiting G-Protein Coupled Receptor Signaling Pathway
  • Gamma-Aminobutyric Acid Signaling Pathway
  • Negative Regulation Of Adenylate Cyclase Activity
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Dopamine Secretion
  • Negative Regulation Of Epinephrine Secretion
  • Negative Regulation Of Gamma-Aminobutyric Acid Secretion
  • Negative Regulation Of Synaptic Transmission
  • Osteoblast Differentiation
  • Positive Regulation Of Glutamate Secretion
  • Positive Regulation Of Growth Hormone Secretion
  • Response To Ethanol
  • Response To Nicotine

Drug Bank:

  • Baclofen
  • Progabide
  • Vigabatrin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| seven transmembrane helix receptor| A306_05510| bM573K1.1| bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a)| CB1_085562010| GABAB1| GABAbR1| GABA-BR1| GABA-B-R1| GABA(B)R1| GABA-BR1b receptor| GABA-B receptor 1| GABA-B receptor, R1 subunit| GABBR1-3| gamma-aminobutyric acid B receptor 1| gamma-aminobutyric acid (GABA) B receptor 1| gamma-aminobutyric acid (GABA) B receptor, 1| GB1| GPRC3A| GW7_10280| H920_13515| I79_015084| M91_05122| MDA_GLEAN10002423| N300_11226| N302_15652| N308_07785| N309_00463| N312_05484| PAL_GLEAN10001316| UY3_09346| Y956_03834| Z169_10508| gabbr1

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