The Function of GABBR1
Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.
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Protein names
Recommended name:
Gamma-aminobutyric acid type B receptor subunit 1Alternative name(s):
GABA-B receptor 1GABA-B-R1
GABA-BR1
GABABR1
Gb1
Top Gene-Substance Interactions
GABBR1 Interacts with These Diseases
| Disease | Score |
Substances That Increase GABBR1
| Substances | Interaction | Organism | Category |
Substances That Decrease GABBR1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.
Molecular Function:
Biological Processes:
- Osteoblast Differentiation
- Adenylate Cyclase-Inhibiting G-Protein Coupled Receptor Signaling Pathway
- Negative Regulation Of Adenylate Cyclase Activity
- Gamma-Aminobutyric Acid Signaling Pathway
- Negative Regulation Of Cell Proliferation
- Positive Regulation Of Glutamate Secretion
- Negative Regulation Of Gamma-Aminobutyric Acid Secretion
- Negative Regulation Of Epinephrine Secretion
- Negative Regulation Of Dopamine Secretion
- Response To Nicotine
- Response To Ethanol
- Negative Regulation Of Synaptic Transmission
- Positive Regulation Of Growth Hormone Secretion