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  3. GAB2

GAB2 (GRB2 associated binding protein 2)

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Summary of GAB2

GAB2 is a member of the GRB2-associated binding protein (GAB) gene family; they help transmit various signals in response to stimuli through cytokine and growth factor receptors (R). 

Overexpression of this gene is associated with Alzheimer's Disease (R). It is also associated with breast, colon, gastric, and ovarian cancer (R). 

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The Function of GAB2

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Protein names

Recommended name:

GRB2-associated-binding protein 2

Alternative name(s):

GRB2-associated binder 2
Growth factor receptor bound protein 2-associated protein 2
pp100

GAB2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10793294 (GAB2) ??
  2. RS10899489 (GAB2) ??
  3. RS1385600 (GAB2) ??
  4. RS2063730 (GAB2) ??
  5. RS2373115 (GAB2) ??
  6. RS4945261 (GAB2) ??
  7. RS7101429 (GAB2) ??

Top Gene-Substance Interactions

GAB2 Interacts with These Diseases

Disease Score

Substances That Increase GAB2

Substances Interaction Organism Category

Substances That Decrease GAB2

Substances Interaction Organism Category

Advanced Summary

GAB2 is a member of the GRB2-associated binding protein (GAB) gene family; they help transmit various signals in response to stimuli through cytokine and growth factor receptors (R). 

Overexpression of this gene is associated with Alzheimer's Disease (R). It is also associated with breast, colon, gastric, and ovarian cancer (R). 

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • STAT5A
  • c-Fos
  • E2F-1

Gene Pathways:

  • Disease
  • Immune System
  • Signal Transduction
  • Chronic myeloid leukemia
  • Osteoclast differentiation
  • Fc epsilon RI signaling pathway

Molecular Function:

  • Phosphatidylinositol-3,4,5-Trisphosphate Binding
  • Phosphatidylinositol-3,4-Bisphosphate Binding
  • Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity

Biological Processes:

  • Fc-Epsilon Receptor Signaling Pathway
  • Osteoclast Differentiation
  • Phosphatidylinositol-Mediated Signaling
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Mast Cell Degranulation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| p97| A306_00183| AS27_05983| AS28_14414| CB1_001567014| Grb2 associated binder 2| Grb2-associated binder 2| GRB2-associated binding protein 2| GRB2-associated-binding protein 2| growth factor receptor bound protein 2-associated protein 2| GW7_00910| H920_09218| I79_020915| M91_18955| M959_12143| MDA_GLEAN10011339| N300_09092| N301_00186| N302_10790| N305_08179| N306_09992| N307_07782| N309_06491| N310_01093| N312_02166| N320_04111| N321_07852| N322_01002| N325_06396| N326_03887| N330_05234| N331_01147| N332_10495| N334_01049| N335_02787| PAL_GLEAN10025543| PANDA_004384| PH domain-containing adaptor molecule p97| pp100| TREES_T100007963| UY3_14295| Y1Q_012310| Y956_06638| Z169_07731| zmp:0000000753| gab2

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