Summary of GAB2
GAB2 is a member of the GRB2-associated binding protein (GAB) gene family; they help transmit various signals in response to stimuli through cytokine and growth factor receptors (R).
Overexpression of this gene is associated with Alzheimer's Disease (R). It is also associated with breast, colon, gastric, and ovarian cancer (R).
The Function of GAB2
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Protein names
Recommended name:
GRB2-associated-binding protein 2Alternative name(s):
GRB2-associated binder 2Growth factor receptor bound protein 2-associated protein 2
pp100
- RS10793294 (GAB2) ??
- RS10899489 (GAB2) ??
- RS1385600 (GAB2) ??
- RS2063730 (GAB2) ??
- RS2373115 (GAB2) ??
- RS4945261 (GAB2) ??
- RS7101429 (GAB2) ??
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Top Gene-Substance Interactions
GAB2 Interacts with These Diseases
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Substances That Increase GAB2
| Substances | Interaction | Organism | Category |
Substances That Decrease GAB2
| Substances | Interaction | Organism | Category |
Advanced Summary
GAB2 is a member of the GRB2-associated binding protein (GAB) gene family; they help transmit various signals in response to stimuli through cytokine and growth factor receptors (R).
Overexpression of this gene is associated with Alzheimer's Disease (R). It is also associated with breast, colon, gastric, and ovarian cancer (R).
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
- Phosphatidylinositol-3,4,5-Trisphosphate Binding
- Phosphatidylinositol-3,4-Bisphosphate Binding
Biological Processes:
- Positive Regulation Of Cell Proliferation
- Osteoclast Differentiation
- Fc-Epsilon Receptor Signaling Pathway
- Positive Regulation Of Mast Cell Degranulation
- Phosphatidylinositol-Mediated Signaling