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  3. FXYD6

FXYD6 (FXYD domain containing ion transport regulator 6)

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Summary of FXYD6

This gene encodes a protein that has an affect on Na,K-ATPase. It is associated with risk for schizophrenia (R).

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Protein names

Recommended name:

FXYD domain-containing ion transport regulator 6

Alternative name(s):

Phosphohippolin

FXYD6 SNPs

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  1. RS4938445 (FXYD6) ??

Top Gene-Substance Interactions

Substances That Increase FXYD6

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Substances That Decrease FXYD6

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Advanced Summary

     From UniProt: Schizophrenia 2 (SCZD2): A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. [MIM:603342]

     From NCBI Gene: This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1

Gene Pathways:

  • Transmembrane transport of small molecules

Molecular Function:

  • Ion Channel Activity

Biological Processes:

  • Ion Transmembrane Transport
  • Regulation Of Cardiac Conduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS28_06490| EGK_06940| FXYD domain-containing ion transport regulator 6| GW7_18649| N303_12992| N312_08424| N320_06640| N331_06515| N332_10165| N333_04616| PANDA_019701| Phosphohippolin| Php| PLM-like protein| vascular endothelial cell-specific protein 6| VESP6| Y956_12597| fxyd6

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