Summary of FXYD6
This gene encodes a protein that has an affect on Na,K-ATPase. It is associated with risk for schizophrenia (R).
Protein names
Recommended name:
FXYD domain-containing ion transport regulator 6Alternative name(s):
Phosphohippolin- RS4938445 (FXYD6) ??
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Top Gene-Substance Interactions
Substances That Increase FXYD6
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Substances That Decrease FXYD6
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Advanced Summary
From UniProt: Schizophrenia 2 (SCZD2): A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. [MIM:603342]
From NCBI Gene: This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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