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  3. FURIN

FURIN (Furin, paired basic amino acid cleaving enzyme)

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Summary of FURIN

This gene encodes  a protein that is part of the secretory pathway (R).

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The Function of FURIN

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

Protein names

Recommended name:

Furin

Short name:

PACE

Alternative name(s):

Dibasic-processing enzyme
Paired basic amino acid residue-cleaving enzyme

FURIN SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17514846 (FURIN) ??
  2. RS4702 (FURIN) ??
  3. RS4932178 (FURIN) ??

Top Gene-Substance Interactions

FURIN Interacts with These Diseases

Disease Score

Substances That Increase FURIN

Substances Interaction Organism Category

Substances That Decrease FURIN

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • TBP
  • TFIID
  • Sox9
  • GCNF

Tissue specificity:

Seems to be expressed ubiquitously.

Gene Pathways:

  • Disease
  • Signal Transduction
  • Metabolism of proteins
  • Extracellular matrix organization

Enzyme Regulation:

Could be inhibited by the not secondly cleaved propeptide.

Molecular Function:

  • Endopeptidase Activity
  • Metal Ion Binding
  • Nerve Growth Factor Binding
  • Peptidase Activity
  • Peptide Binding
  • Protease Binding
  • Serine-Type Endopeptidase Activity
  • Serine-Type Endopeptidase Inhibitor Activity

Biological Processes:

  • Cell Proliferation
  • Cellular Protein Metabolic Process
  • Collagen Catabolic Process
  • Extracellular Matrix Disassembly
  • Extracellular Matrix Organization
  • Negative Regulation Of Low-Density Lipoprotein Particle Receptor Catabolic Process
  • Negative Regulation Of Transforming Growth Factor Beta1 Production
  • Nerve Growth Factor Processing
  • Nerve Growth Factor Production
  • Peptide Biosynthetic Process
  • Peptide Hormone Processing
  • Positive Regulation Of Membrane Protein Ectodomain Proteolysis
  • Protein Processing
  • Regulation Of Endopeptidase Activity
  • Regulation Of Low-Density Lipoprotein Particle Receptor Biosynthetic Process
  • Regulation Of Protein Catabolic Process
  • Regulation Of Signal Transduction
  • Secretion By Cell
  • Signal Peptide Processing
  • Transforming Growth Factor Beta Receptor Signaling Pathway
  • Viral Life Cycle
  • Viral Protein Processing
  • Aging
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_14931| dibasic processing enzyme| dibasic-processing enzyme| EGK_17838| FES upstream region| FUR| Furin-1| furin a| furin, membrane associated receptor protein| furin (paired basic amino acid cleaving enzyme)| furin preproprotein| GW7_08842| H920_03992| MDA_GLEAN10006781| N302_04929| N303_08295| N305_13064| N306_06275| Pace| PACE4| paired basic amino acid cleaving enzyme| Paired basic amino acid cleaving enzyme (furin)| paired basic amino acid residue cleaving enzyme| paired basic amino acid residue-cleaving enzyme| PAL_GLEAN10009514| PANDA_008499| PCSK3| prohormone convertase 3| prohormone convertase PACE4| proprotein convertase subtilisin/kexin type3| proprotein convertase subtilisin/kexin type 3| Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein)| RFURIN| SPC1| subtilisin pro-protein processing enzyme| trans Golgi network protease furin| TREES_T100018704| UY3_06800| xfurin| Z169_16482| furin

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