Summary of FURIN
This gene encodes a protein that is part of the secretory pathway (R).
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The Function of FURIN
Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
Protein names
Recommended name:
FurinShort name:
PACEAlternative name(s):
Dibasic-processing enzymePaired basic amino acid residue-cleaving enzyme
- RS17514846 (FURIN) ??
- RS4702 (FURIN) ??
- RS4932178 (FURIN) ??
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Top Gene-Substance Interactions
FURIN Interacts with These Diseases
| Disease | Score |
Substances That Increase FURIN
| Substances | Interaction | Organism | Category |
Substances That Decrease FURIN
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Seems to be expressed ubiquitously.
Enzyme Regulation:
Could be inhibited by the not secondly cleaved propeptide.
Molecular Function:
- Protease Binding
- Endopeptidase Activity
- Serine-Type Endopeptidase Activity
- Serine-Type Endopeptidase Inhibitor Activity
- Peptidase Activity
- Peptide Binding
- Metal Ion Binding
- Nerve Growth Factor Binding
Biological Processes:
- Signal Peptide Processing
- Transforming Growth Factor Beta Receptor Signaling Pathway
- Aging
- Cell Proliferation
- Regulation Of Signal Transduction
- Protein Processing
- Peptide Hormone Processing
- Viral Life Cycle
- Viral Protein Processing
- Extracellular Matrix Disassembly
- Extracellular Matrix Organization
- Positive Regulation Of Cell Migration
- Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Collagen Catabolic Process
- Nerve Growth Factor Processing
- Negative Regulation Of Low-Density Lipoprotein Particle Receptor Catabolic Process
- Nerve Growth Factor Production
- Negative Regulation Of Transforming Growth Factor Beta1 Production
- Secretion By Cell
- Regulation Of Protein Catabolic Process
- Peptide Biosynthetic Process
- Cellular Protein Metabolic Process
- Regulation Of Low-Density Lipoprotein Particle Receptor Biosynthetic Process
- Positive Regulation Of Membrane Protein Ectodomain Proteolysis
- Regulation Of Endopeptidase Activity