The Function of FTH1
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
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Protein names
Recommended name:
Ferritin heavy chainAlternative name(s):
Ferritin H subunitCell proliferation-inducing gene 15 protein
Top Gene-Substance Interactions
FTH1 Interacts with These Diseases
| Disease | Score |
Substances That Increase FTH1
| Substances | Interaction | Organism | Category |
Substances That Decrease FTH1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the liver.
Gene Pathways:
Molecular Function:
Biological Processes:
- Cellular Iron Ion Homeostasis
- Immune Response
- Intracellular Sequestering Of Iron Ion
- Iron Ion Import
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Fibroblast Proliferation
- Iron Ion Transport
Drug Bank:
- Iron Dextran