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  3. FSHR

FSHR (Follicle stimulating hormone receptor)

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Summary of FSHR

This gene encodes a protein that belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and helps gonad development. Mutations can cause problems with the ovaries (R). 

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The Function of FSHR

Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways.

Protein names

Recommended name:

Follicle-stimulating hormone receptor

Short name:

FSH-R

Alternative name(s):

Follitropin receptor

FSHR SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10495970 (FSHR) ??
  2. RS1394205 (FSHR) ??
  3. RS2268361 (FSHR) ??
  4. RS2268363 (FSHR) ??
  5. RS6165 (FSHR) ??
  6. RS6166 (FSHR) ??
  7. RS7591064 (FSHR) ??
  8. RS9636436 (FSHR) ??

Top Gene-Substance Interactions

FSHR Interacts with These Diseases

Disease Score

Substances That Increase FSHR

Substances Interaction Organism Category

Substances That Decrease FSHR

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Ovarian hyperstimulation syndromeDizygotic twinsOvarian dysgenesis 1From UniProt: Ovarian dysgenesis 1 (ODG1): An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). [MIM:233300] Ovarian hyperstimulation syndrome (OHSS): Disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. [MIM:608115]

     From NCBI Gene: The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] From UniProt: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO1a
  • FOXO1
  • RREB-1
  • USF1
  • USF-1

Tissue specificity:

Sertoli cells and ovarian granulosa cells.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction

Molecular Function:

  • Follicle-Stimulating Hormone Receptor Activity
  • G-Protein Coupled Peptide Receptor Activity

Biological Processes:

  • Activation Of Adenylate Cyclase Activity
  • Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
  • Female Gamete Generation
  • Female Gonad Development
  • Gonad Development
  • G-Protein Coupled Receptor Signaling Pathway
  • Hormone-Mediated Signaling Pathway
  • Male Gonad Development
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
  • Primary Ovarian Follicle Growth
  • Regulation Of Osteoclast Differentiation
  • Regulation Of Protein Kinase A Signaling
  • Spermatogenesis

Drug Bank:

  • Choriogonadotropin Alfa
  • Menotropins
  • Suramin
  • Urofollitropin
  • Follitropin Beta
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_04862| AS27_04353| AS28_00099| CB1_000843030| D623_10033487| eFSHR| EGK_05318| follicle-stimulating hormone receptor| Follitropin receptor| FSH-R| FSHR1| FSHRE| FSH receptor| FSHRO| gonadotropic hormone I| GTHR-I| GW7_16389| H920_20143| I79_005655| LGR1| M959_14100| N300_13470| N303_12270| N306_01327| N307_01843| N309_07634| N310_02174| N312_12810| N320_06203| N321_08812| N322_09842| N325_12765| N326_12449| N327_10696| N328_09228| N329_01107| N330_02282| N331_11447| N332_11390| N334_05599| N335_13670| N336_10055| N339_13105| N340_07886| ODG1| PAL_GLEAN10021263| PANDA_018266| thyroid stimulating hormone receptor| TREES_T100001985| truncated follicle stimulating hormone receptor| TSHR| Y1Q_002319| Y956_15561| zfGTHR-I| fshr

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