Summary of FSHR
This gene encodes a protein that belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and helps gonad development. Mutations can cause problems with the ovaries (R).
The Function of FSHR
Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways.
Protein names
Recommended name:
Follicle-stimulating hormone receptorShort name:
FSH-RAlternative name(s):
Follitropin receptor- RS10495970 (FSHR) ??
- RS1394205 (FSHR) ??
- RS2268361 (FSHR) ??
- RS2268363 (FSHR) ??
- RS6165 (FSHR) ??
- RS6166 (FSHR) ??
- RS7591064 (FSHR) ??
- RS9636436 (FSHR) ??
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Top Gene-Substance Interactions
FSHR Interacts with These Diseases
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Substances That Increase FSHR
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Substances That Decrease FSHR
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Ovarian hyperstimulation syndromeDizygotic twinsOvarian dysgenesis 1From UniProt: Ovarian dysgenesis 1 (ODG1): An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). [MIM:233300] Ovarian hyperstimulation syndrome (OHSS): Disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. [MIM:608115]
From NCBI Gene: The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] From UniProt: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Sertoli cells and ovarian granulosa cells.
Gene Pathways:
Molecular Function:
Biological Processes:
- Primary Ovarian Follicle Growth
- G-Protein Coupled Receptor Signaling Pathway
- Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
- Activation Of Adenylate Cyclase Activity
- Spermatogenesis
- Female Gamete Generation
- Gonad Development
- Male Gonad Development
- Female Gonad Development
- Hormone-Mediated Signaling Pathway
- Regulation Of Protein Kinase A Signaling
- Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Regulation Of Osteoclast Differentiation
- Positive Regulation Of Erk1 And Erk2 Cascade
Drug Bank:
- Choriogonadotropin Alfa
- Menotropins
- Suramin
- Urofollitropin
- Follitropin Beta