The Function of FRY
Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.
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Protein names
Recommended name:
Protein furry homolog- RS7331540 (FRY) ??
- RS9533282 (FRY) ??
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Top Gene-Substance Interactions
FRY Interacts with These Diseases
| Disease | Score |
Substances That Increase FRY
| Substances | Interaction | Organism | Category |
Substances That Decrease FRY
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Cell Morphogenesis
- Neuron Projection Development
- Actin Filament Reorganization
- Negative Regulation Of Tubulin Deacetylation