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  3. FOXF1

FOXF1 (Forkhead box F1)

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The Function of FOXF1

Probable transcription activator for a number of lung-specific genes.

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Protein names

Recommended name:

Forkhead box protein F1

Short name:

FREAC-1

Alternative name(s):

Forkhead-related activator 1
Forkhead-related protein FKHL5
Forkhead-related transcription factor 1

Top Gene-Substance Interactions

Substances That Increase FOXF1

Substances Interaction Organism Category

Substances That Decrease FOXF1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • FOXO4
  • FOXO1a
  • FOXO1

Tissue specificity:

Expressed in lung and placenta.

Developmental stage:

Expressed in fetal lung.

Caution:

It is uncertain whether Met-1 or Met-26 is the initiator.

Molecular Function:

  • Dna Binding
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding

Biological Processes:

  • Blood Vessel Development
  • Branching Involved In Open Tracheal System Development
  • Cardiac Left Ventricle Morphogenesis
  • Cellular Response To Cytokine Stimulus
  • Cellular Response To Organic Cyclic Compound
  • Detection Of Wounding
  • Determination Of Left/Right Symmetry
  • Digestive Tract Development
  • Ductus Arteriosus Closure
  • Embryonic Digestive Tract Morphogenesis
  • Embryonic Ectodermal Digestive Tract Morphogenesis
  • Embryonic Foregut Morphogenesis
  • Endocardial Cushion Development
  • Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
  • Epithelial Tube Branching Involved In Lung Morphogenesis
  • Establishment Of Epithelial Cell Apical/Basal Polarity
  • Extracellular Matrix Organization
  • Heart Development
  • In Utero Embryonic Development
  • Lateral Mesodermal Cell Differentiation
  • Lung Alveolus Development
  • Lung Development
  • Lung Lobe Morphogenesis
  • Lung Vasculature Development
  • Mesenchyme Migration
  • Midgut Development
  • Morphogenesis Of A Branching Structure
  • Negative Regulation Of Inflammatory Response
  • Negative Regulation Of Mast Cell Degranulation
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Pancreas Development
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Cell-Substrate Adhesion
  • Positive Regulation Of Mesenchymal Cell Proliferation
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Smooth Muscle Cell Differentiation
  • Renal System Development
  • Respiratory Tube Development
  • Right Lung Morphogenesis
  • Single Organismal Cell-Cell Adhesion
  • Smoothened Signaling Pathway
  • Smooth Muscle Cell Differentiation
  • Somitogenesis
  • Trachea Development
  • Ureter Development
  • Vasculogenesis
  • Venous Blood Vessel Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_01723| ACDMPV| CB1_000589018| D623_10035307| fkhl5| forkhead box F1a| forkhead box F protein| forkhead box protein F1| Forkhead box protein F1-B| Forkhead, drosophila, homolog-like 5| forkhead-related activator 1| forkhead-related protein FKHL5| forkhead-related transcription factor 1| forkhead transcription factor| foxF| foxf1-a| Foxf1a| foxf1-b| freac1| Freac-1| hepatocyte nuclear factor 3 forkhead homolog 8| Hfh8| HFH-8| HNF-3/forkhead homolog 8| M91_08311| M959_02659| MDA_GLEAN10022627| N300_09611| N301_11716| N302_06890| N305_04817| N307_03674| N321_10936| N330_10218| N339_00723| PAL_GLEAN10025619| PANDA_001236| TREES_T100001653| xfd-13| foxf1

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