The Function of FOXF1
Probable transcription activator for a number of lung-specific genes.
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Protein names
Recommended name:
Forkhead box protein F1Short name:
FREAC-1Alternative name(s):
Forkhead-related activator 1Forkhead-related protein FKHL5
Forkhead-related transcription factor 1
Top Gene-Substance Interactions
Substances That Increase FOXF1
| Substances | Interaction | Organism | Category |
Substances That Decrease FOXF1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in lung and placenta.
Developmental stage:
Expressed in fetal lung.
Caution:
It is uncertain whether Met-1 or Met-26 is the initiator.
Molecular Function:
- Dna Binding
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
Biological Processes:
- Blood Vessel Development
- Branching Involved In Open Tracheal System Development
- Cardiac Left Ventricle Morphogenesis
- Cellular Response To Cytokine Stimulus
- Cellular Response To Organic Cyclic Compound
- Detection Of Wounding
- Determination Of Left/Right Symmetry
- Digestive Tract Development
- Ductus Arteriosus Closure
- Embryonic Digestive Tract Morphogenesis
- Embryonic Ectodermal Digestive Tract Morphogenesis
- Embryonic Foregut Morphogenesis
- Endocardial Cushion Development
- Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
- Epithelial Tube Branching Involved In Lung Morphogenesis
- Establishment Of Epithelial Cell Apical/Basal Polarity
- Extracellular Matrix Organization
- Heart Development
- In Utero Embryonic Development
- Lateral Mesodermal Cell Differentiation
- Lung Alveolus Development
- Lung Development
- Lung Lobe Morphogenesis
- Lung Vasculature Development
- Mesenchyme Migration
- Midgut Development
- Morphogenesis Of A Branching Structure
- Negative Regulation Of Inflammatory Response
- Negative Regulation Of Mast Cell Degranulation
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Pancreas Development
- Positive Regulation Of Cell Migration
- Positive Regulation Of Cell-Substrate Adhesion
- Positive Regulation Of Mesenchymal Cell Proliferation
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Smooth Muscle Cell Differentiation
- Renal System Development
- Respiratory Tube Development
- Right Lung Morphogenesis
- Single Organismal Cell-Cell Adhesion
- Smoothened Signaling Pathway
- Smooth Muscle Cell Differentiation
- Somitogenesis
- Trachea Development
- Ureter Development
- Vasculogenesis
- Venous Blood Vessel Development