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  3. FOXC1

FOXC1 (Forkhead box C1)

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The Function of FOXC1

Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.

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Protein names

Recommended name:

Forkhead box protein C1

Short name:

FREAC-3

Alternative name(s):

Forkhead-related protein FKHL7
Forkhead-related transcription factor 3

Top Gene-Substance Interactions

FOXC1 Interacts with These Diseases

Disease Score

Substances That Increase FOXC1

Substances Interaction Organism Category

Substances That Decrease FOXC1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXI1
  • ARP-1
  • FOXO1a
  • FOXF2
  • FOXO1
  • FOXC1
  • FOXL1

Tissue specificity:

Expressed in all tissues and cell lines examined.

Molecular Function:

  • Dna Binding
  • Dna Binding, Bending
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
  • Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Binding
  • Transcription Regulatory Region Dna Binding

Biological Processes:

  • Artery Morphogenesis
  • Blood Vessel Remodeling
  • Brain Development
  • Camera-Type Eye Development
  • Cardiac Muscle Cell Proliferation
  • Cell Proliferation
  • Collagen Fibril Organization
  • Embryonic Heart Tube Development
  • Eye Development
  • Germ Cell Migration
  • Glycosaminoglycan Metabolic Process
  • Heart Development
  • In Utero Embryonic Development
  • Lacrimal Gland Development
  • Lymph Vessel Development
  • Maintenance Of Lens Transparency
  • Mesenchymal Cell Development
  • Negative Regulation Of Angiogenesis
  • Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis
  • Negative Regulation Of Lymphangiogenesis
  • Negative Regulation Of Mitotic Cell Cycle
  • Neural Crest Cell Development
  • Notch Signaling Pathway
  • Odontogenesis Of Dentin-Containing Tooth
  • Ossification
  • Ovarian Follicle Development
  • Paraxial Mesoderm Formation
  • Positive Regulation Of Hematopoietic Progenitor Cell Differentiation
  • Positive Regulation Of Hematopoietic Stem Cell Differentiation
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Blood Vessel Size
  • Regulation Of Organ Growth
  • Regulation Of Transcription, Dna-Templated
  • Skeletal System Development
  • Somitogenesis
  • Ureteric Bud Development
  • Vascular Endothelial Growth Factor Receptor Signaling Pathway
  • Vascular Endothelial Growth Factor Signaling Pathway
  • Ventricular Cardiac Muscle Tissue Morphogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ARA| CFKH-1| ch| congenital hydrocephalus| fkh-1| Fkh1| fkhl7| forkhead box C1a| forkhead box C1 protein| forkhead box protein C1| Forkhead box protein C1-A| forkhead, drosophila, homolog-like 7| forkhead-related activator 3| forkhead-related protein FKHL7| forkhead-related transcription factor 3| forkhead/winged helix-like transcription factor 7| foxc1-a| foxc1-b| freac3| FREAC-3| frkhda| igda| IHG1| IRID1| MDA_GLEAN10008411| mesoderm/mesenchyme forkhead 1| Mf1| MF-1| Mf4| myeloid factor-delta| N302_06290| N303_03417| PAL_GLEAN10002898| RIEG3| transcription factor FKH-1| UY3_06152| winged helix protein CWH-6| winged-helix transcription factor| xfd-11| Y1Q_029454| foxc1

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