The Function of FOXC1
Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.
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Protein names
Recommended name:
Forkhead box protein C1Short name:
FREAC-3Alternative name(s):
Forkhead-related protein FKHL7Forkhead-related transcription factor 3
Top Gene-Substance Interactions
FOXC1 Interacts with These Diseases
| Disease | Score |
Substances That Increase FOXC1
| Substances | Interaction | Organism | Category |
Substances That Decrease FOXC1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues and cell lines examined.
Molecular Function:
- Dna Binding
- Dna Binding, Bending
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
- Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Artery Morphogenesis
- Blood Vessel Remodeling
- Brain Development
- Camera-Type Eye Development
- Cardiac Muscle Cell Proliferation
- Cell Proliferation
- Collagen Fibril Organization
- Embryonic Heart Tube Development
- Eye Development
- Germ Cell Migration
- Glycosaminoglycan Metabolic Process
- Heart Development
- In Utero Embryonic Development
- Lacrimal Gland Development
- Lymph Vessel Development
- Maintenance Of Lens Transparency
- Mesenchymal Cell Development
- Negative Regulation Of Angiogenesis
- Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis
- Negative Regulation Of Lymphangiogenesis
- Negative Regulation Of Mitotic Cell Cycle
- Neural Crest Cell Development
- Notch Signaling Pathway
- Odontogenesis Of Dentin-Containing Tooth
- Ossification
- Ovarian Follicle Development
- Paraxial Mesoderm Formation
- Positive Regulation Of Hematopoietic Progenitor Cell Differentiation
- Positive Regulation Of Hematopoietic Stem Cell Differentiation
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Blood Vessel Size
- Regulation Of Organ Growth
- Regulation Of Transcription, Dna-Templated
- Skeletal System Development
- Somitogenesis
- Ureteric Bud Development
- Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Vascular Endothelial Growth Factor Signaling Pathway
- Ventricular Cardiac Muscle Tissue Morphogenesis