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FOXA2 (Forkhead box A2)

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Summary of FOXA2

This gene encodes proteins that are transcriptional activators for other genes. It is associated with diabetes in children (R).

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The Function of FOXA2

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Protein names

Recommended name:

Hepatocyte nuclear factor 3-beta

Short name:

HNF-3B

Alternative name(s):

HNF-3-beta
Forkhead box protein A2
Transcription factor 3B
TCF-3B

FOXA2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1209523 (FOXA2) ??
  2. RS6048205 (FOXA2) ??

Top Gene-Substance Interactions

FOXA2 Interacts with These Diseases

Disease Score

Substances That Increase FOXA2

Substances Interaction Organism Category

Substances That Decrease FOXA2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GATA-6
  • HFH-1
  • Nkx2-2
  • FOXC1

Gene Pathways:

  • Maturity onset diabetes of the young

Molecular Function:

  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
  • Dna Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Regulatory Region Dna Binding

Biological Processes:

  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter By Glucose
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter By Glucose
  • Cell Fate Specification
  • Transcription, Dna-Templated
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Adult Locomotory Behavior
  • Negative Regulation Of Epithelial To Mesenchymal Transition
  • Covalent Chromatin Modification
  • Regulation Of Blood Coagulation
  • Endocrine Pancreas Development
  • Negative Regulation Of Glucokinase Activity
  • Positive Regulation Of Embryonic Development
  • Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
  • Response To Interleukin-6
  • Dopaminergic Neuron Differentiation
  • Primitive Streak Formation
  • Positive Regulation Of Cell-Cell Adhesion Mediated By Cadherin
  • Positive Regulation Of Gastrulation
  • Negative Regulation Of Detection Of Glucose
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| axl| ax| axial protein| D623_10017245| etID309811.17| fkd1| fkh| forkhead box protein A2| forkhead box protein A2-like| fork head transcription factor FoxA2| H920_16781| hepatic nuclear factor-3-beta| hepatocyte nuclear factor 3 beta| hepatocyte nuclear factor 3-beta| hepatocyte nuclear factor-3beta| hepatocyte nuclear factor 3 beta (winged helix transcription factor)| Hnf3b| HNF-3B| hnf3-beta| HNF3beta| HNF-3-beta| HNF-3BETA| ik:tdsubc_2g8| M91_21307| M959_03788| MDA_GLEAN10009778| me-hnf3b| Me-HNF3b protein| mol| monorail| N300_10186| N303_00718| N308_05796| N330_00402| PAL_GLEAN10023994| PANDA_013447| tcf3b| Tcf-3b| tdsubc_2g8| transcription factor 3B| transcription factor Foxa2| xx:tdsubc_2g8| Y1Q_003357| Y956_14482| Z169_15655| foxa2

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