Summary of FOXA2
This gene encodes proteins that are transcriptional activators for other genes. It is associated with diabetes in children (R).
The Function of FOXA2
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Protein names
Recommended name:
Hepatocyte nuclear factor 3-betaShort name:
HNF-3BAlternative name(s):
HNF-3-betaForkhead box protein A2
Transcription factor 3B
TCF-3B
- RS1209523 (FOXA2) ??
- RS6048205 (FOXA2) ??
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Top Gene-Substance Interactions
FOXA2 Interacts with These Diseases
| Disease | Score |
Substances That Increase FOXA2
| Substances | Interaction | Organism | Category |
Substances That Decrease FOXA2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter By Glucose
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter By Glucose
- Cell Fate Specification
- Transcription, Dna-Templated
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Adult Locomotory Behavior
- Negative Regulation Of Epithelial To Mesenchymal Transition
- Covalent Chromatin Modification
- Regulation Of Blood Coagulation
- Endocrine Pancreas Development
- Negative Regulation Of Glucokinase Activity
- Positive Regulation Of Embryonic Development
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
- Response To Interleukin-6
- Dopaminergic Neuron Differentiation
- Primitive Streak Formation
- Positive Regulation Of Cell-Cell Adhesion Mediated By Cadherin
- Positive Regulation Of Gastrulation
- Negative Regulation Of Detection Of Glucose