The Function of FOXA1
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
Protein names
Recommended name:
Hepatocyte nuclear factor 3-alphaShort name:
HNF-3AAlternative name(s):
HNF-3-alphaForkhead box protein A1
Transcription factor 3A
TCF-3A
Top Gene-Substance Interactions
FOXA1 Interacts with These Diseases
| Disease | Score |
Substances That Increase FOXA1
| Substances | Interaction | Organism | Category |
Substances That Decrease FOXA1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.
Molecular Function:
- Dna Binding
- Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
- Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Alveolar Secondary Septum Development
- Anatomical Structure Formation Involved In Morphogenesis
- Covalent Chromatin Modification
- Chromatin Remodeling
- Dopaminergic Neuron Differentiation
- Dorsal/Ventral Neural Tube Patterning
- Epithelial Cell Maturation Involved In Prostate Gland Development
- Epithelial-Mesenchymal Signaling Involved In Prostate Gland Development
- Epithelial Tube Branching Involved In Lung Morphogenesis
- Glucose Homeostasis
- Hormone Metabolic Process
- Lung Epithelial Cell Differentiation
- Negative Regulation Of Epithelial To Mesenchymal Transition
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Neuron Fate Specification
- Notch Signaling Pathway
- Positive Regulation Of Cell-Cell Adhesion Mediated By Cadherin
- Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
- Positive Regulation Of Mitotic Cell Cycle
- Positive Regulation Of Neuron Differentiation
- Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Positive Regulation Of Smoothened Signaling Pathway
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Prostate Gland Epithelium Morphogenesis
- Prostate Gland Stromal Morphogenesis
- Respiratory Basal Cell Differentiation
- Response To Estradiol
- Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development