The Function of FOS
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Protein names
Recommended name:
Proto-oncogene c-FosAlternative name(s):
Cellular oncogene fosG0/G1 switch regulatory protein 7
- RS1569328 (FOS) ??
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Top Gene-Substance Interactions
FOS Interacts with These Diseases
| Disease | Score |
Substances That Increase FOS
| Substances | Interaction | Organism | Category |
Substances That Decrease FOS
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Rheumatoid arthritis
- Immune System
- Chagas disease (American trypanosomiasis)
- Pathways in cancer
- Leishmaniasis
- Toll-like receptor signaling pathway
- T cell receptor signaling pathway
- TRAF6 Mediated Induction of proinflammatory cytokines
- Osteoclast differentiation
- Cellular responses to stress
- Colorectal cancer
- MAPK signaling pathway
- B cell receptor signaling pathway
Developmental stage:
Expressed at very low levels in quiescent cells. When cells are stimulated to reenter growth, they undergo 2 waves of expression, the first one peaks 7.5 minutes following FBS induction. At this stage, the protein is localized endoplasmic reticulum. The second wave of expression occurs at about 20 minutes after induction and peaks at 1 hour. At this stage, the protein becomes nuclear.
Molecular Function:
- Chromatin Binding
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
- R-Smad Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Factor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Aging
- Cellular Response To Calcium Ion
- Cellular Response To Extracellular Stimulus
- Cellular Response To Hormone Stimulus
- Cellular Response To Reactive Oxygen Species
- Conditioned Taste Aversion
- Dna Methylation
- Fc-Epsilon Receptor Signaling Pathway
- Female Pregnancy
- Inflammatory Response
- Nervous System Development
- Positive Regulation Of Osteoclast Differentiation
- Positive Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Response To Camp
- Response To Cold
- Response To Corticosterone
- Response To Cytokine
- Response To Gravity
- Response To Immobilization Stress
- Response To Light Stimulus
- Response To Lipopolysaccharide
- Response To Muscle Stretch
- Response To Progesterone
- Response To Toxic Substance
- Skeletal Muscle Cell Differentiation
- Sleep
- Smad Protein Signal Transduction
- Transcription From Rna Polymerase Ii Promoter
- Transforming Growth Factor Beta Receptor Signaling Pathway