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  3. FOS

FOS (Fos proto-oncogene, AP-1 transcription factor subunit)

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The Function of FOS

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

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Protein names

Recommended name:

Proto-oncogene c-Fos

Alternative name(s):

Cellular oncogene fos
G0/G1 switch regulatory protein 7

FOS SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1569328 (FOS) ??

Top Gene-Substance Interactions

FOS Interacts with These Diseases

Disease Score

Substances That Increase FOS

Substances Interaction Organism Category

Substances That Decrease FOS

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • AP-1
  • c-Jun
  • deltaCREB
  • C/EBPbeta
  • c-Fos
  • p300

Gene Pathways:

  • Rheumatoid arthritis
  • Immune System
  • Chagas disease (American trypanosomiasis)
  • Pathways in cancer
  • Leishmaniasis
  • Toll-like receptor signaling pathway
  • T cell receptor signaling pathway
  • TRAF6 Mediated Induction of proinflammatory cytokines
  • Osteoclast differentiation
  • Cellular responses to stress
  • Colorectal cancer
  • MAPK signaling pathway
  • B cell receptor signaling pathway

Developmental stage:

Expressed at very low levels in quiescent cells. When cells are stimulated to reenter growth, they undergo 2 waves of expression, the first one peaks 7.5 minutes following FBS induction. At this stage, the protein is localized endoplasmic reticulum. The second wave of expression occurs at about 20 minutes after induction and peaks at 1 hour. At this stage, the protein becomes nuclear.

Molecular Function:

  • Chromatin Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
  • R-Smad Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Factor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Binding
  • Transcription Regulatory Region Dna Binding

Biological Processes:

  • Aging
  • Cellular Response To Calcium Ion
  • Cellular Response To Extracellular Stimulus
  • Cellular Response To Hormone Stimulus
  • Cellular Response To Reactive Oxygen Species
  • Conditioned Taste Aversion
  • Dna Methylation
  • Fc-Epsilon Receptor Signaling Pathway
  • Female Pregnancy
  • Inflammatory Response
  • Nervous System Development
  • Positive Regulation Of Osteoclast Differentiation
  • Positive Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Response To Camp
  • Response To Cold
  • Response To Corticosterone
  • Response To Cytokine
  • Response To Gravity
  • Response To Immobilization Stress
  • Response To Light Stimulus
  • Response To Lipopolysaccharide
  • Response To Muscle Stretch
  • Response To Progesterone
  • Response To Toxic Substance
  • Skeletal Muscle Cell Differentiation
  • Sleep
  • Smad Protein Signal Transduction
  • Transcription From Rna Polymerase Ii Promoter
  • Transforming Growth Factor Beta Receptor Signaling Pathway

Drug Bank:

  • Nadroparin
  • Pseudoephedrine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| transcription factor protein| p55| activator protein 1| AP-1| CB1_000743081| cellular oncogene c-fos| cellular oncogene fos| cFos| C-FOS| c-fos oncogene| c-Fos protein| c-fos proto-oncogene| c-fos proto-oncogene protein| c-fos protooncogene protein| D12Rfj1| EGK_18393| FBJ murine osteosarcoma viral oncogene homolog| FBJ murine osteosarcoma viral oncogene-like protein| FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)| FBJ osteosarcoma oncogene| Fos proto-oncogene, AP-1 trancription factor subunit| Fos-related antigen 2| G0/G1 switch regulatory protein 7| GW7_01438| H920_14393| I79_009428| M91_20353| murine FBJ osteosarcoma viral (v-fos) oncogene homolog| N307_11567| N309_07576| N320_08391| N334_14258| PAL_GLEAN10020665| PANDA_002685| protein transport protein Sec61 subunit gamma| proto-oncogene c-Fos| proto-oncogene cFOS| proto-oncogene protein cFOS| Proto-oncogene protein c-fos| TREES_T100010373| UY3_12119| v-fos FBJ murine osteosarcoma viral oncogene homolog| v-fos FBJ murine osteosarcoma viral oncogene-like protein| v-fos FBJ murine osteosarcoma viral oncoprotein-like protein| xfos| Y1Q_004771| fos

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