The Function of FOLR1
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
Protein names
Recommended name:
Folate receptor alphaShort name:
FBPAlternative name(s):
FR-alphaAdult folate-binding protein
Folate receptor 1
Folate receptor, adult
KB cells FBP
Ovarian tumor-associated antigen MOv18
Top Gene-Substance Interactions
FOLR1 Interacts with These Diseases
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Substances That Increase FOLR1
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Substances That Decrease FOLR1
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Advanced Summary
cerebral folate transport deficiency At least 11 mutations in the FOLR1 gene have been found to cause cerebral folate transport deficiency, a disorder characterized by neurological problems that begin around age 2. Most of these mutations change single protein building blocks (amino acids) in folate receptor alpha. FOLR1 gene mutations result in a lack of protein or malfunctioning protein. Without folate receptor alpha in brain cells, 5-MTHF in the bloodstream cannot be transported into the CSF and passed to the brain. A shortage (deficiency) of folate in the brain impairs normal cell functions such as the production of DNA, proteins, and neurotransmitters. Folate deficiency affects the stability of myelin, leading to impaired production or increased breakdown of this tissue, a condition known as leukodystrophy. These brain abnormalities caused by a lack of folate lead to the intellectual disability, movement problems, and recurrent seizures (epilepsy) typical of cerebral folate transport deficiency.
The FOLR1 gene provides instructions for making a protein called folate receptor alpha. This protein helps regulate transport of the B-vitamin folate into cells. Folate (also called vitamin B9) is needed for many processes, including the production and repair of DNA, regulation of gene activity (expression), and protein production. Folate from food is absorbed in the intestines and then released in a form called 5-methyl-tetrahydrofolate (5-MTHF) into the bloodstream, where it can be taken in by cells in various tissues. Folate receptor alpha is found within the cell membrane, where it attaches (binds) to 5-MTHF, allowing the vitamin to be brought into the cell. Folate receptor alpha is produced in largest amounts in the brain, specifically in an area of the brain called the choroid plexus. This region releases cerebrospinal fluid (CSF), which surrounds and protects the brain and spinal cord. Folate receptor alpha is thought to play a major role in transporting folate from the bloodstream into brain cells. It transports folate across the choroid plexus and into the CSF, ultimately reaching the brain. In the brain, folate is needed for making chemical messengers called neurotransmitters and a fatty substance called myelin, which insulates nerve fibers and promotes the rapid transmission of nerve impulses. Both of these substances play essential roles in transmitting signals in the nervous system.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.
Molecular Function:
- Drug Binding
- Folic Acid Binding
- Folic Acid Receptor Activity
- Folic Acid Transporter Activity
- Methotrexate Binding
- Receptor Activity
Biological Processes:
- Anterior Neural Tube Closure
- Axon Regeneration
- Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
- Cellular Response To Folic Acid
- Copii Vesicle Coating
- Er To Golgi Vesicle-Mediated Transport
- Folic Acid Metabolic Process
- Folic Acid Transport
- Heart Looping
- Neural Crest Cell Migration Involved In Heart Formation
- Pharyngeal Arch Artery Morphogenesis
- Receptor-Mediated Endocytosis
- Regulation Of Canonical Wnt Signaling Pathway
- Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway