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  3. FOLH1

FOLH1 (Folate hydrolase 1)

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Summary of FOLH1

Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

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Protein names

Recommended name:

Glutamate carboxypeptidase 2

Short name:

PSM

Alternative name(s):

Cell growth-inhibiting gene 27 protein
Folate hydrolase 1
Folylpoly-gamma-glutamate carboxypeptidase
FGCP
Glutamate carboxypeptidase II
GCPII
Membrane glutamate carboxypeptidase
mGCP
N-acetylated-alpha-linked acidic dipeptidase I
NAALADase I
Prostate-specific membrane antigen
PSMA
Pteroylpoly-gamma-glutamate carboxypeptidase

FOLH1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS202676 (FOLH1) ??
  2. RS202712 (FOLH1) ??

Top Gene-Substance Interactions

FOLH1 Interacts with These Diseases

Disease Score

Substances That Increase FOLH1

Substances Interaction Organism Category

Substances That Decrease FOLH1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-3 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer.

Gene Pathways:

  • Vitamin digestion and absorption

Induction:

In the prostate, up-regulated in response to androgen deprivation.

Enzyme Regulation:

The NAALADase activity is inhibited by beta-NAAG, quisqualic acid, 2-(phosphonomethyl) pentanedioic acid (PMPA) and EDTA. Activated by cobalt.

Cofactor:

Binds 2 Zn(2+) ions per subunit. Required for NAALADase activity.

Molecular Function:

  • Ac-Asp-Glu Binding
  • Dipeptidase Activity
  • Metal Ion Binding
  • Metallocarboxypeptidase Activity
  • Peptidase Activity
  • Tetrahydrofolyl-Poly(Glutamate) Polymer Binding

Biological Processes:

  • Cellular Amino Acid Biosynthetic Process
  • C-Terminal Protein Deglutamylation
  • Folic Acid-Containing Compound Metabolic Process
  • Proteolysis

Drug Bank:

  • Capromab
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| GCP2| cell growth-inhibiting gene 27 protein| FGCP| folate hydrolase (prostate-specific membrane antigen) 1| FOLH| folylpoly-gamma-glutamate carboxypeptidase| GCPII| glutamate carboxylase II| glutamate carboxypeptidase 2| glutamate carboxypeptidase II| membrane glutamate carboxypeptidase| mGCP| mopsm| Naalad| NAALAD1| NAALAdase| NAALADase I| N-acetylated alpha-linked acidic dipeptidase| N-acetylated alpha-linked acidic dipeptidase 1| N-acetylated-alpha-linked acidic dipeptidase I| prostate-specific membrane antigen| prostate-specific membrane antigen homolog| prostate specific membrane antigen variant F| PSM| PSMA| pteroylpoly-gamma-glutamate carboxypeptidase| putative N-acetylated-alpha-linked acidic dipeptidase| folh1

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