Summary of FOLH1
Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Protein names
Recommended name:
Glutamate carboxypeptidase 2Short name:
PSMAlternative name(s):
Cell growth-inhibiting gene 27 proteinFolate hydrolase 1
Folylpoly-gamma-glutamate carboxypeptidase
FGCP
Glutamate carboxypeptidase II
GCPII
Membrane glutamate carboxypeptidase
mGCP
N-acetylated-alpha-linked acidic dipeptidase I
NAALADase I
Prostate-specific membrane antigen
PSMA
Pteroylpoly-gamma-glutamate carboxypeptidase
- RS202676 (FOLH1) ??
- RS202712 (FOLH1) ??
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Top Gene-Substance Interactions
FOLH1 Interacts with These Diseases
Disease | Score |
Substances That Increase FOLH1
Substances | Interaction | Organism | Category |
Substances That Decrease FOLH1
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-3 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer.
Gene Pathways:
Induction:
In the prostate, up-regulated in response to androgen deprivation.
Enzyme Regulation:
The NAALADase activity is inhibited by beta-NAAG, quisqualic acid, 2-(phosphonomethyl) pentanedioic acid (PMPA) and EDTA. Activated by cobalt.
Cofactor:
Binds 2 Zn(2+) ions per subunit. Required for NAALADase activity.
Molecular Function:
- Ac-Asp-Glu Binding
- Dipeptidase Activity
- Metal Ion Binding
- Metallocarboxypeptidase Activity
- Peptidase Activity
- Tetrahydrofolyl-Poly(Glutamate) Polymer Binding
Biological Processes:
- Cellular Amino Acid Biosynthetic Process
- C-Terminal Protein Deglutamylation
- Folic Acid-Containing Compound Metabolic Process
- Proteolysis
Drug Bank:
- Capromab