The Function of FMR1
(Microbial infection) Acts as a positive regulator of influenza A virus (IAV) replication. Required for the assembly and nuclear export of the viral ribonucleoprotein (vRNP) components.
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Protein names
Recommended name:
Synaptic functional regulator FMR1Short name:
FMRPAlternative name(s):
Fragile X mental retardation protein 1Protein FMR-1
- RS5904818 (FMR1) ??
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Top Gene-Substance Interactions
FMR1 Interacts with These Diseases
| Disease | Score |
Substances That Increase FMR1
| Substances | Interaction | Organism | Category |
Substances That Decrease FMR1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the brain, cerebellum and testis (PubMed:8401578). Also expressed in epithelial tissues (PubMed:8401578). Expressed in mature oligodendrocytes (OLGs) (PubMed:23891804). Expressed in fibroblast (PubMed:24204304). Expressed in neurons, Purkinje cells and spermatogonias (at protein level) (PubMed:8401578). Expressed in brain, testis and placenta (PubMed:8504300). Expressed in neurons and lymphocytes (PubMed:8504300).
Induction:
(Microbial infection) Up-regulated in response to infection by influenza A virus.
Molecular Function:
- G-Quadruplex Rna Binding
- Chromatin Binding
- Rna Binding
- Mrna Binding
- Mrna 3'-Utr Binding
- Microtubule Binding
- Poly(U) Rna Binding
- Translation Repressor Activity
- Translation Initiation Factor Binding
- Rna Strand Annealing Activity
- Poly(G) Binding
- Methylated Histone Binding
- Sirna Binding
- Mirna Binding
- Rna Stem-Loop Binding
- Identical Protein Binding
- Protein Homodimerization Activity
- Ribosome Binding
- Ion Channel Binding
- Poly(A) Rna Binding
- Dynein Binding
- Protein Heterodimerization Activity
- Mrna 5'-Utr Binding
- Sequence-Specific Mrna Binding
Biological Processes:
- Regulation Of Alternative Mrna Splicing, Via Spliceosome
- Positive Regulation Of Receptor Internalization
- Mrna Processing
- Cellular Response To Dna Damage Stimulus
- Glutamate Receptor Signaling Pathway
- Rna Splicing
- Negative Regulation Of Translation
- Gene Silencing By Rna
- Positive Regulation Of Histone Phosphorylation
- Cellular Response To Uv
- Regulation Of Mrna Stability
- Modulation By Host Of Viral Rna Genome Replication
- Positive Regulation Of Translation
- Negative Regulation Of Translational Initiation
- Regulation Of Neurotransmitter Secretion
- Mrna Transport
- Regulation Of Filopodium Assembly
- Positive Regulation Of Filopodium Assembly
- Regulation Of Gene Silencing By Mirna
- Regulation Of Dendritic Spine Development
- Positive Regulation Of Dendritic Spine Development
- Cellular Response To Hydroxyurea
- Cellular Response To Virus
- Regulation Of Neuronal Action Potential
- Negative Regulation Of Long Term Synaptic Depression
- Positive Regulation Of Intracellular Transport Of Viral Material
- Negative Regulation Of Voltage-Gated Calcium Channel Activity
- Positive Regulation Of Proteasomal Protein Catabolic Process
- Positive Regulation Of Mrna Binding
- Negative Regulation Of Synaptic Vesicle Exocytosis
- Positive Regulation Of Gene Silencing By Mirna
- Negative Regulation Of Cytoplasmic Translation
- Positive Regulation Of Response To Dna Damage Stimulus