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  3. FMR1

FMR1 (Fragile X mental retardation 1)

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The Function of FMR1

(Microbial infection) Acts as a positive regulator of influenza A virus (IAV) replication. Required for the assembly and nuclear export of the viral ribonucleoprotein (vRNP) components.

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Protein names

Recommended name:

Synaptic functional regulator FMR1

Short name:

FMRP

Alternative name(s):

Fragile X mental retardation protein 1
Protein FMR-1

FMR1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS5904818 (FMR1) ??

Top Gene-Substance Interactions

FMR1 Interacts with These Diseases

Disease Score

Substances That Increase FMR1

Substances Interaction Organism Category

Substances That Decrease FMR1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Sp1
  • USF1
  • USF-1

Tissue specificity:

Expressed in the brain, cerebellum and testis (PubMed:8401578). Also expressed in epithelial tissues (PubMed:8401578). Expressed in mature oligodendrocytes (OLGs) (PubMed:23891804). Expressed in fibroblast (PubMed:24204304). Expressed in neurons, Purkinje cells and spermatogonias (at protein level) (PubMed:8401578). Expressed in brain, testis and placenta (PubMed:8504300). Expressed in neurons and lymphocytes (PubMed:8504300).

Induction:

(Microbial infection) Up-regulated in response to infection by influenza A virus.

Molecular Function:

  • Chromatin Binding
  • Dynein Binding
  • G-Quadruplex Rna Binding
  • Identical Protein Binding
  • Ion Channel Binding
  • Methylated Histone Binding
  • Microtubule Binding
  • Mirna Binding
  • Mrna 3'-Utr Binding
  • Mrna 5'-Utr Binding
  • Mrna Binding
  • Poly(A) Rna Binding
  • Poly(G) Binding
  • Poly(U) Rna Binding
  • Protein Heterodimerization Activity
  • Protein Homodimerization Activity
  • Ribosome Binding
  • Rna Binding
  • Rna Stem-Loop Binding
  • Rna Strand Annealing Activity
  • Sequence-Specific Mrna Binding
  • Sirna Binding
  • Translation Initiation Factor Binding
  • Translation Repressor Activity

Biological Processes:

  • Cellular Response To Dna Damage Stimulus
  • Cellular Response To Hydroxyurea
  • Cellular Response To Uv
  • Cellular Response To Virus
  • Gene Silencing By Rna
  • Glutamate Receptor Signaling Pathway
  • Modulation By Host Of Viral Rna Genome Replication
  • Mrna Processing
  • Mrna Transport
  • Negative Regulation Of Cytoplasmic Translation
  • Negative Regulation Of Long Term Synaptic Depression
  • Negative Regulation Of Synaptic Vesicle Exocytosis
  • Negative Regulation Of Translation
  • Negative Regulation Of Translational Initiation
  • Negative Regulation Of Voltage-Gated Calcium Channel Activity
  • Positive Regulation Of Dendritic Spine Development
  • Positive Regulation Of Filopodium Assembly
  • Positive Regulation Of Gene Silencing By Mirna
  • Positive Regulation Of Histone Phosphorylation
  • Positive Regulation Of Intracellular Transport Of Viral Material
  • Positive Regulation Of Mrna Binding
  • Positive Regulation Of Proteasomal Protein Catabolic Process
  • Positive Regulation Of Receptor Internalization
  • Positive Regulation Of Response To Dna Damage Stimulus
  • Positive Regulation Of Translation
  • Regulation Of Alternative Mrna Splicing, Via Spliceosome
  • Regulation Of Dendritic Spine Development
  • Regulation Of Filopodium Assembly
  • Regulation Of Gene Silencing By Mirna
  • Regulation Of Mrna Stability
  • Regulation Of Neuronal Action Potential
  • Regulation Of Neurotransmitter Secretion
  • Rna Splicing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_15097| Anapl_02515| Antho-RFamide neuropeptides type 1| AS27_02156| AS28_00351| AT24755| BcDNA:GM08679| CB1_002254001| CG6203 gene product from transcript CG6203-RC| CG6203-PA| CG6203-PB| CG6203-PC| CG6203-PD| CG6203-PE| CG6203-PF| CG6203-PG| CG6203-PH| CG6203-PI| CG6203-PJ| CG6203-PK| dfmr| dFMR1| dFMRP| dfxr| dfxr1| dFXRP| Dmel_CG6203| dmfr1| drosophila fragile X mental retardation protein| EP(3)3517| FMR| Fmr-1| fmr1-a| fmr1-b| Fmr1-PA| Fmr1-PB| Fmr1-PC| Fmr1-PD| Fmr1-PE| Fmr1-PF| Fmr1-PG| Fmr1-PH| Fmr1-PI| Fmr1-PJ| Fmr1-PK| Fmrp| fragile X| fragile-X| fragile X mental retardation| fragile X mental retardation-1 protein| Fragile X mental retardation 1 protein| fragile X mental retardation 1 protein isoform ISO1| fragile X mental retardation 1 protein isoform ISO7| fragile X mental retardation 1 protein isoform ISO9| fragile X mental retardation gene| fragile X mental retardation-like protein| fragile X mental retardation protein| Fragile-X mental retardation protein| fragile X mental retardation protein 1| Fragile X mental retardation protein 1 B| Fragile X mental retardation protein 1 homolog| fragile X mental retardation protein 1 isoform ISO1| fragile X mental retardation protein 1 isoform ISO7| fragile X mental retardation protein 1 isoform ISO9| fragile X mental retardation protein 1-like B| Fragile X mental retardation protein 1 like protein| fragile X mental retardation syndrome 1| fragile X mental retardation syndrome 1 homolog| fragile X mental retardation syndrome 1 isoform 15-like protein| fragile X protein| fragile x related| fragile X-related| Fragile-X-related| fragile X related protein| fraxa| FXR| I79_012168| M91_05031| M959_07999| MDA_GLEAN10004765| N301_14440| N302_09355| N303_11633| N305_05440| N306_15068| N307_08953| N309_09829| N311_09074| N312_04556| N320_03872| N321_09750| N322_13623| N324_01728| N325_02946| N327_07937| N328_02888| N329_08682| N330_11823| N331_11532| N333_00792| N334_14382| N335_14014| N336_10172| N339_02283| N341_06655| PAL_GLEAN10002878| PANDA_007294| POF| POF1| protein FMR-1| ragile X mental retardation protein| synaptic functional regulator FMR1| TREES_T100019067| UY3_07335| xtFmrp| Y1Q_023482| Y956_02410| Z169_12310| zFMR1| fmr1

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