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  3. FMO2

FMO2 (Flavin containing monooxygenase 2)

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Summary of FMO2

This gene encodes a protein that helps with the oxidation of alkylamines (R).

0 users want this gene increased, 0 users want it decreased

The Function of FMO2

Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.

Protein names

Recommended name:

Dimethylaniline monooxygenase [N-oxide-forming] 4

Short name:

FMO 4

Alternative name(s):

Dimethylaniline oxidase 4
Hepatic flavin-containing monooxygenase 4

FMO2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2020862 (FMO2) ??
  2. RS2020865 (FMO2) ??
  3. RS6661174 (FMO2) ??

Top Gene-Substance Interactions

FMO2 Interacts with These Diseases

Disease Score

Substances That Increase FMO2

Substances Interaction Organism Category

Substances That Decrease FMO2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • C/EBPalpha
  • Hlf
  • FAC1
  • YY1
  • FOXC1
  • Sox5
  • NCX/Ncx

Tissue specificity:

Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain.

Gene Pathways:

  • Metabolism
  • Drug metabolism - cytochrome P450

Molecular Function:

  • Flavin Adenine Dinucleotide Binding
  • Monooxygenase Activity
  • N,N-Dimethylaniline Monooxygenase Activity
  • Nadp Binding

Biological Processes:

  • Drug Metabolic Process
  • Nadph Oxidation
  • Nadp Metabolic Process
  • Organic Acid Metabolic Process
  • Oxygen Metabolic Process
  • Toxin Metabolic Process
  • Xenobiotic Metabolic Process
  • Drug Catabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CB1_001676001| dimethylaniline monooxygenase (N-oxide-forming) 2| dimethylaniline monooxygenase [N-oxide-forming] 2| Dimethylaniline monooxygenase N-oxide-forming 2| dimethylaniline oxidase 2| flavin-containing monooxygenase| flavin containing monooxygenase 2 (non-functional)| flavin containing monooxygenase 4| flavin-dependent monooxygenase FMO2| FMO1B1| FMO 1B1| FMO 2| FMO-2| fmo3| FMO4| FMO, pulmonary| I79_012735| PAL_GLEAN10017812| PANDA_018459| pulmonary flavin-containing monooxygenase 2| pulmonary flavin-containing monooxygenase 2 (Dimethylaniline oxidase 2) (FMO 1B1)| UY3_08368| fmo2

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