Summary of FMO2
This gene encodes a protein that helps with the oxidation of alkylamines (R).
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The Function of FMO2
Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.
Protein names
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 4Short name:
FMO 4Alternative name(s):
Dimethylaniline oxidase 4Hepatic flavin-containing monooxygenase 4
- RS2020862 (FMO2) ??
- RS2020865 (FMO2) ??
- RS6661174 (FMO2) ??
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Top Gene-Substance Interactions
FMO2 Interacts with These Diseases
| Disease | Score |
Substances That Increase FMO2
| Substances | Interaction | Organism | Category |
Substances That Decrease FMO2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain.
Gene Pathways:
Molecular Function:
- Monooxygenase Activity
- N,N-Dimethylaniline Monooxygenase Activity
- Flavin Adenine Dinucleotide Binding
- Nadp Binding
Biological Processes:
- Organic Acid Metabolic Process
- Nadp Metabolic Process
- Xenobiotic Metabolic Process
- Toxin Metabolic Process
- Drug Metabolic Process
- Drug Catabolic Process
- Nadph Oxidation
- Oxygen Metabolic Process