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  3. FMO1

FMO1 (Flavin containing monooxygenase 1)

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The Function of FMO1

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

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Protein names

Recommended name:

Dimethylaniline monooxygenase [N-oxide-forming] 1

Short name:

FMO 1

Alternative name(s):

Dimethylaniline oxidase 1
Fetal hepatic flavin-containing monooxygenase 1

FMO1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6660565 (FMO1) ??

Top Gene-Substance Interactions

FMO1 Interacts with These Diseases

Disease Score

Substances That Increase FMO1

Substances Interaction Organism Category

Substances That Decrease FMO1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • YY1

Tissue specificity:

Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.

Gene Pathways:

  • Metabolism
  • Drug metabolism - cytochrome P450

Molecular Function:

  • Flavin Adenine Dinucleotide Binding
  • Monooxygenase Activity
  • N,N-Dimethylaniline Monooxygenase Activity
  • Nadp Binding

Biological Processes:

  • Drug Metabolic Process
  • Nadph Oxidation
  • Organic Acid Metabolic Process
  • Response To Lipopolysaccharide
  • Response To Osmotic Stress
  • Toxin Metabolic Process
  • Xenobiotic Metabolic Process

Drug Bank:

  • Cevimeline
  • Lorcaserin
  • Vandetanib
  • Voriconazole
  • Cimetidine
  • Tamoxifen
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13494| CB1_001676002| dimethylaniline monooxygenase [N-oxide-forming] 1| dimethylaniline monooxygenase [N-oxide-forming] 4| dimethylaniline oxidase 1| fetal hepatic flavin-containing monooxygenase 1| Flavin-containing monooxygenase 1| Flavin-containing monooxygenase 1 (fetal liver)| flavin-dependent monooxygenase FMO1| FMO 1| FMO 1A1| FMO form 1| H920_15716| hepatic flavin-containing monooxygenase 1| hepatic flavin-containing monooxygenase (FMO)| M959_12562| MDA_GLEAN10014783| N305_07585| N324_01443| N325_11321| N340_06368| PAL_GLEAN10017810| PANDA_018458| RFMO1A| TREES_T100009742| fmo1

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