The Function of FMO1
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.
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Protein names
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 1Short name:
FMO 1Alternative name(s):
Dimethylaniline oxidase 1Fetal hepatic flavin-containing monooxygenase 1
- RS6660565 (FMO1) ??
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Top Gene-Substance Interactions
FMO1 Interacts with These Diseases
| Disease | Score |
Substances That Increase FMO1
| Substances | Interaction | Organism | Category |
Substances That Decrease FMO1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.
Gene Pathways:
Molecular Function:
- Monooxygenase Activity
- N,N-Dimethylaniline Monooxygenase Activity
- Flavin Adenine Dinucleotide Binding
- Nadp Binding
Biological Processes:
- Organic Acid Metabolic Process
- Xenobiotic Metabolic Process
- Response To Osmotic Stress
- Toxin Metabolic Process
- Drug Metabolic Process
- Response To Lipopolysaccharide
- Nadph Oxidation
Drug Bank:
- Cevimeline
- Lorcaserin
- Vandetanib
- Voriconazole
- Cimetidine
- Tamoxifen