The Function of FGF9
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
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Protein names
Recommended name:
Fibroblast growth factor 9Short name:
GAFAlternative name(s):
FGF-9Glia-activating factor
Heparin-binding growth factor 9
HBGF-9
- RS518590 (FGF9) ??
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Top Gene-Substance Interactions
FGF9 Interacts with These Diseases
| Disease | Score |
Substances That Increase FGF9
| Substances | Interaction | Organism | Category |
Substances That Decrease FGF9
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Glial cells.
Gene Pathways:
Molecular Function:
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Growth Factor Activity
- Heparin Binding
- 1-Phosphatidylinositol-3-Kinase Activity
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Mapk Cascade
- Angiogenesis
- Osteoblast Differentiation
- Eye Development
- Positive Regulation Of Mesenchymal Cell Proliferation
- Chondrocyte Differentiation
- Protein Import Into Nucleus
- Signal Transduction
- Cell-Cell Signaling
- Positive Regulation Of Cell Proliferation
- Fibroblast Growth Factor Receptor Signaling Pathway
- Male Gonad Development
- Positive Regulation Of Gene Expression
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Substantia Nigra Development
- Negative Regulation Of Wnt Signaling Pathway
- Male Sex Determination
- Embryonic Limb Morphogenesis
- Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Activin Receptor Signaling Pathway
- Inner Ear Morphogenesis
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Smoothened Signaling Pathway
- Phosphatidylinositol-Mediated Signaling
- Regulation Of Timing Of Cell Differentiation
- Embryonic Digestive Tract Development
- Embryonic Skeletal System Development
- Positive Regulation Of Epithelial Cell Proliferation
- Positive Regulation Of Cell Division
- Positive Regulation Of Cardiac Muscle Cell Proliferation
- Lung-Associated Mesenchyme Development
- Positive Regulation Of Canonical Wnt Signaling Pathway