The Function of FGF4
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
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Protein names
Recommended name:
Fibroblast growth factor 4Short name:
HSTAlternative name(s):
FGF-4Heparin secretory-transforming protein 1
HST-1
HSTF-1
Heparin-binding growth factor 4
HBGF-4
Transforming protein KS3
- RS10796849 (FGF4) ??
- RS12808519 (FGF4) ??
- RS4084127 (FGF4) ??
- RS734102 (FGF4) ??
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Top Gene-Substance Interactions
Substances That Increase FGF4
| Substances | Interaction | Organism | Category |
Substances That Decrease FGF4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Growth Factor Activity
- Heparin Binding
- 1-Phosphatidylinositol-3-Kinase Activity
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
Biological Processes:
- Mapk Cascade
- Cartilage Condensation
- Signal Transduction
- Cell-Cell Signaling
- Positive Regulation Of Cell Proliferation
- Fibroblast Growth Factor Receptor Signaling Pathway
- Mesenchymal Cell Proliferation
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Stem Cell Population Maintenance
- Embryonic Hindlimb Morphogenesis
- Odontogenesis Of Dentin-Containing Tooth
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Cell Division
- Cranial Suture Morphogenesis
- Apoptotic Process Involved In Morphogenesis
- Chondroblast Differentiation
- Positive Regulation Of Erk1 And Erk2 Cascade
- Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Drug Bank:
- Pentosan Polysulfate