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  3. FGF4

FGF4 (Fibroblast growth factor 4)

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The Function of FGF4

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.

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Protein names

Recommended name:

Fibroblast growth factor 4

Short name:

HST

Alternative name(s):

FGF-4
Heparin secretory-transforming protein 1
HST-1
HSTF-1
Heparin-binding growth factor 4
HBGF-4
Transforming protein KS3

FGF4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10796849 (FGF4) ??
  2. RS12808519 (FGF4) ??
  3. RS4084127 (FGF4) ??
  4. RS734102 (FGF4) ??

Top Gene-Substance Interactions

Substances That Increase FGF4

Substances Interaction Organism Category

Substances That Decrease FGF4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CBF-B
  • NF-YB
  • Sp1
  • p300
  • Tal-1

Gene Pathways:

  • Disease
  • Immune System
  • MAPK signaling pathway
  • Melanoma
  • Pathways in cancer
  • Regulation of actin cytoskeleton
  • Signal Transduction

Molecular Function:

  • 1-Phosphatidylinositol-3-Kinase Activity
  • Growth Factor Activity
  • Heparin Binding
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
  • Protein Tyrosine Kinase Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity

Biological Processes:

  • Apoptotic Process Involved In Morphogenesis
  • Cartilage Condensation
  • Cell-Cell Signaling
  • Chondroblast Differentiation
  • Cranial Suture Morphogenesis
  • Embryonic Hindlimb Morphogenesis
  • Fibroblast Growth Factor Receptor Signaling Pathway
  • Mapk Cascade
  • Mesenchymal Cell Proliferation
  • Negative Regulation Of Apoptotic Process
  • Odontogenesis Of Dentin-Containing Tooth
  • Phosphatidylinositol-Mediated Signaling
  • Positive Regulation Of Cell Division
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
  • Regulation Of Phosphatidylinositol 3-Kinase Signaling
  • Signal Transduction
  • Stem Cell Population Maintenance

Drug Bank:

  • Pentosan Polysulfate
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_10818| AS27_06612| AS28_03722| efgf| fc89b01| Fgf-4| fgf4-a| fgf4-b| fgfe| Fgfk| fibroblast growth factor 4B-like| fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)| fibroblast growth factor 4 splice isoform| GW7_00305| HBGF-4| heparin-binding growth factor 1| heparin-binding growth factor 4| heparin secretory-transforming protein| heparin secretory transforming protein 1| HST| Hst1| HST-1| Hstf-1| HSTF1| human stomach cancer, transforming factor from FGF-related oncogene| I79_018315| kaposi sarcoma oncogene| kfgf| K-FGF| K-fibroblast growth factor| KS3| M91_19944| M959_09238| N300_02423| N301_01164| N302_08657| N308_05640| N309_09245| oncogene HST| PANDA_017812| transforming protein KS3| TREES_T100012714| XEFGF| Xfgf4| Xfgf-4| Y1Q_007262| Y956_04493| Z169_11122| fgf4

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