Summary of FGF20
This gene encodes a protein that helps regulate the nervous system. It is associated with Parkinson's disease (R).
The Function of FGF20
Neurotrophic factor that regulates central nervous development and function.
Protein names
Recommended name:
Fibroblast growth factor 20Short name:
FGF-20- RS1094732 (FGF20) ??
- RS12720208 (FGF20) ??
- RS1523643 (FGF20) ??
- RS1721100 (FGF20) ??
- RS1989754 (FGF20) ??
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Top Gene-Substance Interactions
Substances That Increase FGF20
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Substances That Decrease FGF20
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Advanced Summary
From NCBI Gene: Renal hypodysplasia/aplasia 2From UniProt: Renal hypodysplasia/aplasia 2 (RHDA2): A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy. [MIM:615721]
From NCBI Gene: The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009] From UniProt: Neurotrophic factor that regulates central nervous development and function.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Predominantly expressed in the cerebellum.
Gene Pathways:
Caution:
It is uncertain whether variants in this gene are associated with Parkinson disease. Some authors mention association with the disease (PubMed:18252210). In contrast, some others do not observe any association (PubMed:19133659).
Molecular Function:
- 1-Phosphatidylinositol-3-Kinase Activity
- Growth Factor Activity
- Heparan Sulfate Proteoglycan Binding
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Receptor Binding
Biological Processes:
- Cell-Cell Signaling
- Fibroblast Growth Factor Receptor Signaling Pathway
- Inner Ear Receptor Cell Differentiation
- Mapk Cascade
- Negative Regulation Of Neuron Apoptotic Process
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Dopaminergic Neuron Differentiation
- Positive Regulation Of Erk1 And Erk2 Cascade
- Regulation Of Cardiac Muscle Cell Proliferation
- Regulation Of Dopamine Secretion
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Signal Transduction