• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. FGF2

FGF2 (Fibroblast growth factor 2)

Loading...

Summary of FGF2

This gene encodes a protein that plays a role in the immune system and in tumor growth (R).

0 users want this gene increased, 0 users want it decreased

The Function of FGF2

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis (PubMed:23469107).

Protein names

Recommended name:

Fibroblast growth factor 2

Alternative name(s):

FGF-2
Basic fibroblast growth factor
bFGF
Heparin-binding growth factor 2
HBGF-2

FGF2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1048201 (FGF2) ??
  2. RS10518406 (FGF2) ??
  3. RS1449683 (FGF2) ??
  4. RS167428 (FGF2) ??
  5. RS3747676 (FGF2) ??

Top Gene-Substance Interactions

FGF2 Interacts with These Diseases

Disease Score

Substances That Increase FGF2

Substances Interaction Organism Category

Substances That Decrease FGF2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • AP-1
  • AhR
  • c-Jun
  • Pax-6
  • PPAR-alpha
  • c-Fos
  • STAT1
  • FOXC1
  • Sox5

Tissue specificity:

Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.

Gene Pathways:

  • Immune System
  • Melanoma
  • Pathways in cancer
  • MAPK signaling pathway
  • Signal Transduction
  • Disease
  • Regulation of actin cytoskeleton
  • Extracellular matrix organization

Molecular Function:

  • 1-Phosphatidylinositol-3-Kinase Activity
  • Chemoattractant Activity
  • Cytokine Activity
  • Fibroblast Growth Factor Receptor Binding
  • Growth Factor Activity
  • Heparin Binding
  • Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
  • Protein Tyrosine Kinase Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity

Biological Processes:

  • Activation Of Mapk Activity
  • Animal Organ Morphogenesis
  • Branching Involved In Ureteric Bud Morphogenesis
  • Cell Migration Involved In Sprouting Angiogenesis
  • Chemotaxis
  • Chondroblast Differentiation
  • Embryonic Morphogenesis
  • Extracellular Matrix Organization
  • Fibroblast Growth Factor Receptor Signaling Pathway
  • Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation
  • Hyaluronan Catabolic Process
  • Inositol Phosphate Biosynthetic Process
  • Mapk Cascade
  • Negative Regulation Of Blood Vessel Endothelial Cell Migration
  • Negative Regulation Of Cell Death
  • Negative Regulation Of Fibroblast Migration
  • Negative Regulation Of Wound Healing
  • Nervous System Development
  • Phosphatidylinositol Biosynthetic Process
  • Phosphatidylinositol-Mediated Signaling
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Blood Vessel Endothelial Cell Migration
  • Positive Regulation Of Cardiac Muscle Cell Proliferation
  • Positive Regulation Of Cell Division
  • Positive Regulation Of Cell Fate Specification
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
  • Positive Regulation Of Endothelial Cell Proliferation
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Map Kinase Activity
  • Positive Regulation Of Phosphatidylinositol 3-Kinase Activity
  • Positive Regulation Of Phospholipase C Activity
  • Positive Regulation Of Sprouting Angiogenesis
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Ras Protein Signal Transduction
  • Regulation Of Angiogenesis
  • Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
  • Regulation Of Phosphatidylinositol 3-Kinase Signaling
  • Release Of Sequestered Calcium Ion Into Cytosol
  • Signal Transduction
  • Somatic Stem Cell Population Maintenance
  • Wound Healing

Drug Bank:

  • Pentosan Polysulfate
  • Sucralfate
  • Sirolimus
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| prostatropin| angiogenesis promoting growth factor| AS27_00508| AS28_07664| basic fgf| basic fibroblast growth factor| basic fibroblast growth factor bFGF| bfgf| EH28_19668| Fgf-2| fgfb| fibroblast growth factor 2 (basic)| growth factor 2| HBGF2| HBGF-2| hbgh-2| heparin binding growth factor| Heparin-binding growth factor 2| M959_05096| MDA_GLEAN10021184| N300_14061| N301_15478| N305_11074| N307_15145| N308_06235| N320_08588| N324_04008| N328_04071| N329_09048| N331_10674| N332_09148| N335_09686| N336_01283| PANDA_009104| Prostatic growth factor| putative heparin-binding growth factor 1-like protein| UY3_04224| XELAEV_18005606mg| xfgf2| Y1Q_019653| fgf2

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved