Summary of FGF2
This gene encodes a protein that plays a role in the immune system and in tumor growth (R).
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The Function of FGF2
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis (PubMed:23469107).
Protein names
Recommended name:
Fibroblast growth factor 2Alternative name(s):
FGF-2Basic fibroblast growth factor
bFGF
Heparin-binding growth factor 2
HBGF-2
- RS1048201 (FGF2) ??
- RS10518406 (FGF2) ??
- RS1449683 (FGF2) ??
- RS167428 (FGF2) ??
- RS3747676 (FGF2) ??
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Top Gene-Substance Interactions
FGF2 Interacts with These Diseases
| Disease | Score |
Substances That Increase FGF2
| Substances | Interaction | Organism | Category |
Substances That Decrease FGF2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
Gene Pathways:
Molecular Function:
- 1-Phosphatidylinositol-3-Kinase Activity
- Chemoattractant Activity
- Cytokine Activity
- Fibroblast Growth Factor Receptor Binding
- Growth Factor Activity
- Heparin Binding
- Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
Biological Processes:
- Activation Of Mapk Activity
- Animal Organ Morphogenesis
- Branching Involved In Ureteric Bud Morphogenesis
- Cell Migration Involved In Sprouting Angiogenesis
- Chemotaxis
- Chondroblast Differentiation
- Embryonic Morphogenesis
- Extracellular Matrix Organization
- Fibroblast Growth Factor Receptor Signaling Pathway
- Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation
- Hyaluronan Catabolic Process
- Inositol Phosphate Biosynthetic Process
- Mapk Cascade
- Negative Regulation Of Blood Vessel Endothelial Cell Migration
- Negative Regulation Of Cell Death
- Negative Regulation Of Fibroblast Migration
- Negative Regulation Of Wound Healing
- Nervous System Development
- Phosphatidylinositol Biosynthetic Process
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Blood Vessel Endothelial Cell Migration
- Positive Regulation Of Cardiac Muscle Cell Proliferation
- Positive Regulation Of Cell Division
- Positive Regulation Of Cell Fate Specification
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
- Positive Regulation Of Endothelial Cell Proliferation
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Map Kinase Activity
- Positive Regulation Of Phosphatidylinositol 3-Kinase Activity
- Positive Regulation Of Phospholipase C Activity
- Positive Regulation Of Sprouting Angiogenesis
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Ras Protein Signal Transduction
- Regulation Of Angiogenesis
- Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Release Of Sequestered Calcium Ion Into Cytosol
- Signal Transduction
- Somatic Stem Cell Population Maintenance
- Wound Healing
Drug Bank:
- Pentosan Polysulfate
- Sucralfate
- Sirolimus