Summary of FGF2
This gene encodes a protein that plays a role in the immune system and in tumor growth (R).
0 users want this gene increased,
0 users want it decreased
The Function of FGF2
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis (PubMed:23469107).
Protein names
Recommended name:
Fibroblast growth factor 2Alternative name(s):
FGF-2Basic fibroblast growth factor
bFGF
Heparin-binding growth factor 2
HBGF-2
- RS1048201 (FGF2) ??
- RS10518406 (FGF2) ??
- RS1449683 (FGF2) ??
- RS167428 (FGF2) ??
- RS3747676 (FGF2) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
FGF2 Interacts with These Diseases
| Disease | Score |
Substances That Increase FGF2
| Substances | Interaction | Organism | Category |
Substances That Decrease FGF2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
Gene Pathways:
Molecular Function:
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Fibroblast Growth Factor Receptor Binding
- Cytokine Activity
- Growth Factor Activity
- Heparin Binding
- 1-Phosphatidylinositol-3-Kinase Activity
- Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
- Chemoattractant Activity
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
Biological Processes:
- Mapk Cascade
- Activation Of Mapk Activity
- Branching Involved In Ureteric Bud Morphogenesis
- Positive Regulation Of Endothelial Cell Proliferation
- Cell Migration Involved In Sprouting Angiogenesis
- Phosphatidylinositol Biosynthetic Process
- Chemotaxis
- Signal Transduction
- Ras Protein Signal Transduction
- Nervous System Development
- Positive Regulation Of Cell Proliferation
- Fibroblast Growth Factor Receptor Signaling Pathway
- Animal Organ Morphogenesis
- Negative Regulation Of Fibroblast Migration
- Positive Regulation Of Phospholipase C Activity
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation
- Extracellular Matrix Organization
- Hyaluronan Catabolic Process
- Inositol Phosphate Biosynthetic Process
- Somatic Stem Cell Population Maintenance
- Wound Healing
- Positive Regulation Of Cell Fate Specification
- Positive Regulation Of Map Kinase Activity
- Positive Regulation Of Blood Vessel Endothelial Cell Migration
- Negative Regulation Of Blood Vessel Endothelial Cell Migration
- Positive Regulation Of Phosphatidylinositol 3-Kinase Activity
- Regulation Of Angiogenesis
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Phosphatidylinositol-Mediated Signaling
- Embryonic Morphogenesis
- Release Of Sequestered Calcium Ion Into Cytosol
- Positive Regulation Of Cell Division
- Positive Regulation Of Cardiac Muscle Cell Proliferation
- Negative Regulation Of Cell Death
- Chondroblast Differentiation
- Negative Regulation Of Wound Healing
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Sprouting Angiogenesis
- Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
- Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Drug Bank:
- Pentosan Polysulfate
- Sucralfate
- Sirolimus