The Function of FGF18
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.
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Protein names
Recommended name:
Fibroblast growth factor 18Alternative name(s):
FGF-18zFGF5
- RS4620037 (FGF18) ??
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Top Gene-Substance Interactions
Substances That Increase FGF18
| Substances | Interaction | Organism | Category |
Substances That Decrease FGF18
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- 1-Phosphatidylinositol-3-Kinase Activity
- Growth Factor Activity
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Type 1 Fibroblast Growth Factor Receptor Binding
- Type 2 Fibroblast Growth Factor Receptor Binding
Biological Processes:
- Anatomical Structure Morphogenesis
- Angiogenesis
- Cell-Cell Signaling
- Chondrocyte Development
- Endochondral Ossification
- Fibroblast Growth Factor Receptor Signaling Pathway
- Intramembranous Ossification
- Lung Development
- Mapk Cascade
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Chondrocyte Differentiation
- Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Map Kinase Activity
- Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Signal Transduction