The Function of FGF18
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.
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Protein names
Recommended name:
Fibroblast growth factor 18Alternative name(s):
FGF-18zFGF5
- RS4620037 (FGF18) ??
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Top Gene-Substance Interactions
Substances That Increase FGF18
| Substances | Interaction | Organism | Category |
Substances That Decrease FGF18
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Type 1 Fibroblast Growth Factor Receptor Binding
- Type 2 Fibroblast Growth Factor Receptor Binding
- Growth Factor Activity
- 1-Phosphatidylinositol-3-Kinase Activity
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
Biological Processes:
- Mapk Cascade
- Angiogenesis
- Intramembranous Ossification
- Endochondral Ossification
- Chondrocyte Development
- Signal Transduction
- Cell-Cell Signaling
- Positive Regulation Of Cell Proliferation
- Fibroblast Growth Factor Receptor Signaling Pathway
- Anatomical Structure Morphogenesis
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Lung Development
- Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Chondrocyte Differentiation
- Positive Regulation Of Map Kinase Activity
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor