The Function of FGF10
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
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Protein names
Recommended name:
Fibroblast growth factor 10Short name:
FGF-10Alternative name(s):
Keratinocyte growth factor 2- RS2121875 (FGF10) ??
- RS4296809 (FGF10) ??
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Top Gene-Substance Interactions
FGF10 Interacts with These Diseases
| Disease | Score |
Substances That Increase FGF10
| Substances | Interaction | Organism | Category |
Substances That Decrease FGF10
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Fibroblast Growth Factor Receptor Binding
- Type 2 Fibroblast Growth Factor Receptor Binding
- Growth Factor Activity
- Heparin Binding
- 1-Phosphatidylinositol-3-Kinase Activity
- Chemoattractant Activity
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
Biological Processes:
- Establishment Of Mitotic Spindle Orientation
- Mapk Cascade
- Activation Of Mapk Activity
- Angiogenesis
- Metanephros Development
- Organ Induction
- Mesonephros Development
- Blood Vessel Remodeling
- Metanephros Morphogenesis
- Determination Of Left/Right Symmetry
- Salivary Gland Development
- Negative Regulation Of Cell Proliferation
- Fibroblast Growth Factor Receptor Signaling Pathway
- Regulation Of Smoothened Signaling Pathway
- Embryonic Pattern Specification
- Epithelial Cell Migration
- Positive Regulation Of Epithelial Cell Migration
- Positive Regulation Of Keratinocyte Proliferation
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Pituitary Gland Development
- Embryonic Genitalia Morphogenesis
- Thyroid Gland Development
- Otic Vesicle Formation
- Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Pancreas Development
- Hair Follicle Morphogenesis
- Embryonic Camera-Type Eye Development
- Actin Cytoskeleton Reorganization
- Positive Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle
- Response To Estradiol
- Response To Lipopolysaccharide
- Positive Regulation Of Atpase Activity
- Lacrimal Gland Development
- Regulation Of Activin Receptor Signaling Pathway
- Protein Localization To Cell Surface
- Somatic Stem Cell Population Maintenance
- Wound Healing
- Tissue Regeneration
- Odontogenesis Of Dentin-Containing Tooth
- Muscle Cell Fate Commitment
- Positive Regulation Of Mapk Cascade
- Keratinocyte Proliferation
- Negative Regulation Of Cell Differentiation
- Positive Regulation Of Dna Repair
- Positive Regulation Of Dna Replication
- Positive Regulation Of Notch Signaling Pathway
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Mitotic Cell Cycle
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Ras Protein Signal Transduction
- Regulation Of Saliva Secretion
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Fibroblast Proliferation
- Spleen Development
- Thymus Development
- Embryonic Digestive Tract Morphogenesis
- Branching Morphogenesis Of An Epithelial Tube
- Female Genitalia Morphogenesis
- Male Genitalia Morphogenesis
- Positive Regulation Of Lymphocyte Proliferation
- Epithelial Cell Proliferation
- Urothelial Cell Proliferation
- Positive Regulation Of Urothelial Cell Proliferation
- Positive Regulation Of Epithelial Cell Proliferation
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- White Fat Cell Differentiation
- Positive Chemotaxis
- Induction Of Positive Chemotaxis
- Smooth Muscle Cell Differentiation
- Positive Regulation Of Keratinocyte Migration
- Radial Glial Cell Differentiation
- Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing
- Limb Bud Formation
- Lung Epithelium Development
- Lung Saccule Development
- Bronchiole Morphogenesis
- Bud Outgrowth Involved In Lung Branching
- Bud Elongation Involved In Lung Branching
- Mesenchymal-Epithelial Cell Signaling Involved In Lung Development
- Type Ii Pneumocyte Differentiation
- Prostatic Bud Formation
- Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification
- Mammary Gland Bud Formation
- Submandibular Salivary Gland Formation
- Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
- Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-Epithelial Signaling
- Branch Elongation Involved In Salivary Gland Morphogenesis
- Semicircular Canal Fusion
- Mesenchymal Cell Differentiation Involved In Lung Development
- Secretion By Lung Epithelial Cell Involved In Lung Growth
- Lung Proximal/Distal Axis Specification
- Tear Secretion
- Positive Regulation Of White Fat Cell Proliferation
- Erk1 And Erk2 Cascade
- Positive Regulation Of Erk1 And Erk2 Cascade
- Harderian Gland Development
- Negative Regulation Of Cell Cycle Arrest
- Positive Regulation Of Hair Follicle Cell Proliferation
- Positive Regulation Of Canonical Wnt Signaling Pathway
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand