The Function of FGF1
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
Protein names
Recommended name:
Fibroblast growth factor 1Alternative name(s):
FGF-1Acidic fibroblast growth factor
aFGF
Endothelial cell growth factor
ECGF
Heparin-binding growth factor 1
HBGF-1
- RS152439 (FGF1) ??
- RS152528 (FGF1) ??
- RS17099388 (FGF1) ??
- RS17577085 (FGF1) ??
- RS3850579 (FGF1) ??
- RS6890562 (FGF1) ??
- RS6893858 (FGF1) ??
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Top Gene-Substance Interactions
FGF1 Interacts with These Diseases
| Disease | Score |
Substances That Increase FGF1
| Substances | Interaction | Organism | Category |
Substances That Decrease FGF1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
Gene Pathways:
Molecular Function:
- 1-Phosphatidylinositol-3-Kinase Activity
- Fibroblast Growth Factor Receptor Binding
- Growth Factor Activity
- Heparin Binding
- Integrin Binding
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- S100 Protein Binding
Biological Processes:
- Activation Of Mapk Activity
- Activation Of Protein Kinase B Activity
- Anatomical Structure Morphogenesis
- Angiogenesis
- Branch Elongation Involved In Ureteric Bud Branching
- Cell Differentiation
- Cell Proliferation
- Cellular Response To Heat
- Fibroblast Growth Factor Receptor Signaling Pathway
- Lung Development
- Mapk Cascade
- Mesonephric Epithelium Development
- Multicellular Organism Development
- Organ Induction
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Cell Division
- Positive Regulation Of Cell Migration
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Cholesterol Biosynthetic Process
- Positive Regulation Of Endothelial Cell Migration
- Positive Regulation Of Epithelial Cell Proliferation
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Intracellular Signal Transduction
- Positive Regulation Of Map Kinase Activity
- Positive Regulation Of Sprouting Angiogenesis
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
- Regulation Of Endothelial Tube Morphogenesis
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Signal Transduction