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  3. FGF1

FGF1 (Fibroblast growth factor 1)

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The Function of FGF1

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).

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Protein names

Recommended name:

Fibroblast growth factor 1

Alternative name(s):

FGF-1
Acidic fibroblast growth factor
aFGF
Endothelial cell growth factor
ECGF
Heparin-binding growth factor 1
HBGF-1

FGF1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS152439 (FGF1) ??
  2. RS152528 (FGF1) ??
  3. RS17099388 (FGF1) ??
  4. RS17577085 (FGF1) ??
  5. RS3850579 (FGF1) ??
  6. RS6890562 (FGF1) ??
  7. RS6893858 (FGF1) ??

Top Gene-Substance Interactions

FGF1 Interacts with These Diseases

Disease Score

Substances That Increase FGF1

Substances Interaction Organism Category

Substances That Decrease FGF1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • p53
  • CREB
  • AP-1
  • Max
  • c-Jun
  • NF-kappaB1

Tissue specificity:

Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.

Gene Pathways:

  • Disease
  • Immune System
  • MAPK signaling pathway
  • Melanoma
  • Pathways in cancer
  • Regulation of actin cytoskeleton
  • Signal Transduction

Molecular Function:

  • 1-Phosphatidylinositol-3-Kinase Activity
  • Fibroblast Growth Factor Receptor Binding
  • Growth Factor Activity
  • Heparin Binding
  • Integrin Binding
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
  • Protein Tyrosine Kinase Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity
  • S100 Protein Binding

Biological Processes:

  • Activation Of Mapk Activity
  • Activation Of Protein Kinase B Activity
  • Anatomical Structure Morphogenesis
  • Angiogenesis
  • Branch Elongation Involved In Ureteric Bud Branching
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Response To Heat
  • Fibroblast Growth Factor Receptor Signaling Pathway
  • Lung Development
  • Mapk Cascade
  • Mesonephric Epithelium Development
  • Multicellular Organism Development
  • Organ Induction
  • Phosphatidylinositol-Mediated Signaling
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Cell Division
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Cholesterol Biosynthetic Process
  • Positive Regulation Of Endothelial Cell Migration
  • Positive Regulation Of Epithelial Cell Proliferation
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Intracellular Signal Transduction
  • Positive Regulation Of Map Kinase Activity
  • Positive Regulation Of Sprouting Angiogenesis
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
  • Regulation Of Endothelial Tube Morphogenesis
  • Regulation Of Phosphatidylinositol 3-Kinase Signaling
  • Signal Transduction

Drug Bank:

  • Pentosan Polysulfate
  • Amlexanox
  • Pazopanib
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Dffrx| Fam| acidic eye-derived growth factor II| acidic fgf| Acidic fibroblast growth factor| acidic fibroblast growth factor, aFGF| aFGF| alpha-endothelial cell growth factor| AS27_12113| AS28_00694| beta-endothelial cell growth factor| CB1_000740049| ecgf| ECGFA| ECGFB| ECGF-beta| EDGF| EDGF II| EGK_16969| endothelial cell growth factor| endothelial cell growth factor, alpha| endothelial cell growth factor, beta| endothelial cell growth factor beta and alpha chains| endothelial growth factor| Fgf-1| fgfa| fgf-alpha| fibroblast growth factor 1 (acidic)| fibroblast growth factor 1 (acidic) isoform 1| fibroblast growth factor 1 (acidic) isoform A| fibroblast growth factor 1 (acidic) isoform B| Fibroblast growth factor 1 (heparin binding)| fibroblast growth factor, acidic| glio703| GW7_10596| H920_19310| hbgf1| HBGF-1| Heparin-binding growth factor 1| heparin-binding growth factor 1 isoform 1 proprotein| heparin-binding growth factor 1-like protein| M959_03925| N300_11002| N301_09229| N302_05395| N305_06808| N306_02136| N307_00735| N309_08416| N310_01978| N311_08309| N312_02361| N321_06836| N324_09548| N325_03847| N326_08432| N330_07290| N331_00852| N332_03406| N333_09098| N339_04311| N340_02585| N341_03767| PAL_GLEAN10016710| PANDA_000337| prostatropin| putative heparin-binding growth factor 1| TREES_T100021453| UY3_10608| Y1Q_019690| Y956_06271| Z169_00060| fgf1

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